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| - | ==Crystal structure of human adenovirus at 3.5A==
| + | #REDIRECT [[6cgv]] This PDB entry is obsolete and replaced by 6cgv |
| - | <StructureSection load='1vsz' size='340' side='right' caption='[[1vsz]], [[Resolution|resolution]] 3.50Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[1vsz]] is a 20 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_adenovirus_5 Human adenovirus 5]. The December 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Adenovirus'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_12 10.2210/rcsb_pdb/mom_2010_12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VSZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1VSZ FirstGlance]. <br>
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| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1p30|1p30]], [[1x9p|1x9p]], [[1x9t|1x9t]], [[2bld|2bld]], [[2bvi|2bvi]]</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vsz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vsz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1vsz RCSB], [http://www.ebi.ac.uk/pdbsum/1vsz PDBsum]</span></td></tr>
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| - | </table>
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| - | <div style="background-color:#fffaf0;">
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| - | == Publication Abstract from PubMed ==
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| - | Rational development of adenovirus vectors for therapeutic gene transfer is hampered by the lack of accurate structural information. Here, we report the x-ray structure at 3.5 angstrom resolution of the 150-megadalton adenovirus capsid containing nearly 1 million amino acids. We describe interactions between the major capsid protein (hexon) and several accessory molecules that stabilize the capsid. The virus structure also reveals an altered association between the penton base and the trimeric fiber protein, perhaps reflecting an early event in cell entry. The high-resolution structure provides a substantial advance toward understanding the assembly and cell entry mechanisms of a large double-stranded DNA virus and provides new opportunities for improving adenovirus-mediated gene transfer.
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| - | Crystal structure of human adenovirus at 3.5 A resolution.,Reddy VS, Natchiar SK, Stewart PL, Nemerow GR Science. 2010 Aug 27;329(5995):1071-5. PMID:20798318<ref>PMID:20798318</ref>
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| - | </div>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Adenovirus]]
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| - | [[Category: Human adenovirus 5]]
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| - | [[Category: RCSB PDB Molecule of the Month]]
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| - | [[Category: Natchiar, S K]]
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| - | [[Category: Nemerow, G R]]
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| - | [[Category: Reddy, V S]]
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| - | [[Category: Capsid]]
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| - | [[Category: Icosahedral virus]]
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| - | [[Category: Virus]]
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