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6fm6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the class C beta-lactamase TRU-1 from Aeromonas enteropelogenes== | |
| + | <StructureSection load='6fm6' size='340' side='right' caption='[[6fm6]], [[Resolution|resolution]] 1.05Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6fm6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FM6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FM6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fm6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fm6 OCA], [http://pdbe.org/6fm6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fm6 RCSB], [http://www.ebi.ac.uk/pdbsum/6fm6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fm6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | beta-lactamases (BLs) are important antibiotic resistance determinants that significantly compromise the efficacy of valuable beta-lactam antibacterial drugs. For that reason, combinations with beta-lactamase inhibitor were developed. Avibactam is the first non-beta-lactam BL inhibitor introduced in clinical practice. Ceftazidime-avibactam represents one of the few last-resort antibiotics available for the treatment of infections caused by near pandrug-resistant bacteria. TRU-1 is a chromosomally-encoded AmpC-type BL of Aeromonas enteropelogenes, related to the FOX-type BLs and constitutes a good model for class C BLs. TRU-1 crystals provided ultra-high resolution diffraction data for the native enzyme and for its complex with avibactam. The comparison of the native and avibactam-bound structures revealed new details in the conformations of residues relevant for substrate and/or inhibitor binding. Furthermore, the comparison of the TRU-1 and P. aeruginosa AmpC avibactam-bound structures revealed two inhibitor conformations likely corresponding to two different states occurring during inhibitor carbamylation/recyclization. | ||
| - | + | The Atomic Resolution Structure of a Class C beta-lactamase and of its Complex with Avibactam.,Mangani S, Pozzi C, Di Pisa F, De Luca F, Benvenuti M, Docquier JD ChemMedChem. 2018 May 22. doi: 10.1002/cmdc.201800213. PMID:29786960<ref>PMID:29786960</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6fm6" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Beta-lactamase]] | ||
[[Category: Benvenuti, M]] | [[Category: Benvenuti, M]] | ||
| - | [[Category: | + | [[Category: Docquier, J D]] |
| + | [[Category: Luca, F De]] | ||
[[Category: Mangani, S]] | [[Category: Mangani, S]] | ||
| - | [[Category: | + | [[Category: Pisa, F Di]] |
| - | + | ||
[[Category: Pozzi, C]] | [[Category: Pozzi, C]] | ||
| + | [[Category: Aeromonas enteropelogene]] | ||
| + | [[Category: Class c]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Serine beta-lactamase]] | ||
| + | [[Category: Tru-1]] | ||
Revision as of 05:39, 30 May 2018
Crystal structure of the class C beta-lactamase TRU-1 from Aeromonas enteropelogenes
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