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==Your Heading Here (maybe something like 'Structure')== | ==Your Heading Here (maybe something like 'Structure')== | ||
<StructureSection load='1acj_au' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1acj_au' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | <scene name='78/789340/Tacrine_in_active_site/ | + | <scene name='78/789340/Tacrine_in_active_site/4'>Tacrine in active site</scene><ref>PMID:21638687</ref> to the rescue. |
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| + | 1ACJ* shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine | ||
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| + | Tacrine was the first cholinesterase inhibitor approved for the treatment of Alzheimer's disease. | ||
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| + | Tacrine’s ringed structure is stacked between the aromatic rings of Trp84 and Phe330<ref>PMID:8415649</ref> | ||
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| + | [http://pross.weizmann.ac.il http://pross.weizmann.ac.il ] | ||
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| + | <scene name='78/789340/Label_-_2/2'>Label-2</scene> | ||
== Function == | == Function == | ||
Current revision
Your Heading Here (maybe something like 'Structure')
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References
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
- ↑ Harel M, Schalk I, Ehret-Sabatier L, Bouet F, Goeldner M, Hirth C, Axelsen PH, Silman I, Sussman JL. Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):9031-5. PMID:8415649
