Glycosyltransferase

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Line 108: Line 108:
**[[5v2j]], [[5v2k]], [[5u6s]] – AtGT + UDP + laminaribiose + Br-benzoate<br />
**[[5v2j]], [[5v2k]], [[5u6s]] – AtGT + UDP + laminaribiose + Br-benzoate<br />
**[[5u6n]], [[5u6m]] – AtGT + UDP + laminaribiose + salicilate<br />
**[[5u6n]], [[5u6m]] – AtGT + UDP + laminaribiose + salicilate<br />
 +
**[[5tme]], [[5tmb]] – rGT OS 79 + UDP - rice <br />
 +
**[[6bk0]], [[6bk1]], [[6bk2]] - rGT OS 79 (mutant) + UDP <br />
 +
**[[5tmd]], [[6bk3]] – rGT OS 79 + UDP derivative + trichothecene<br />
 +
**[[5xvm]] - yGT 51 – yeast<br />
 +
**[[5gl5]] - yGT 51 + UDP-glucose <br />
*Flavonoid GT
*Flavonoid GT
Line 124: Line 129:
**[[4mnr]] – GT D,D transpeptidase domain – ''Eggerthella lenta''<br />
**[[4mnr]] – GT D,D transpeptidase domain – ''Eggerthella lenta''<br />
**[[4n1x]], [[4qjg]], [[4r1g]], [[4r23]], [[4r3j]], [[4ra7]] – ApGT penicillin-binding domain + penicillin<br />
**[[4n1x]], [[4qjg]], [[4r1g]], [[4r23]], [[4r3j]], [[4ra7]] – ApGT penicillin-binding domain + penicillin<br />
-
**[[4qjg]], [[rr0q]] – ApGT penicillin-binding domain + antibiotic<br />
+
**[[4qjg]], [[4r0q]] – ApGT penicillin-binding domain + antibiotic<br />
**[[5uy7]] – GT – ''Burkholderia ambifaria''<br />
**[[5uy7]] – GT – ''Burkholderia ambifaria''<br />
 +
**[[6bar]] – TtGT RODA – ''Thermus thermophilus''<br />
 +
**[[6bas]] – TtGT RODA (mutant) <br />
*Various GT
*Various GT
Line 180: Line 187:
**[[1g9r]] - GT (mutant) + UDP-galactose + Mn – ''Neisseria meningitides''<br />
**[[1g9r]] - GT (mutant) + UDP-galactose + Mn – ''Neisseria meningitides''<br />
**[[3wag]] – ShGT + DTDP<br />
**[[3wag]] – ShGT + DTDP<br />
-
**[[5tme]], [[5tmb]] – rGT + UDP - rice<br />
 
-
**[[5tmd]] – rGT + UDP derivative + trichothecene<br />
 
-
**[[5gl5]] - GT + UDP-glucose – yeast<br />
 
**[[5ekp]] - SyGT + UDP – ''Synechosystis''<br />
**[[5ekp]] - SyGT + UDP – ''Synechosystis''<br />
**[[5eke]] - SyGT (mutant) + UDP <br />
**[[5eke]] - SyGT (mutant) + UDP <br />
**[[5e9u]], [[5e9t]] - GT + UDP + GlcNac + GT chaperone – ''Streptococcus gordonii''<br />
**[[5e9u]], [[5e9t]] - GT + UDP + GlcNac + GT chaperone – ''Streptococcus gordonii''<br />
 +
**[[6ejj]] - CjGT + nerylneryl pyrophosphate + UDP - ''Campylobacter jejuni''<br />
 +
**[[6eji]] - CjGT + UDP-galactosamine <br />
 +
**[[6ejk]] - CjGT + nerylneryl pyrophosphate + UDP-galactosamine <br />
 +
**[[5v4a]] - GT + UDP – ''Streptococcus sanguinis''<br />
*β-1,4-galactosyltransferase (BGT)
*β-1,4-galactosyltransferase (BGT)

Revision as of 08:39, 5 June 2018

Cyclodextrin glycosyltransferase complex with substrate maltoheptaose, maltose and Ca+2 ions, 1cxh

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3D structures of glycosyltransferase

Updated on 05-June-2018

References

  1. Williams GJ, Thorson JS. Natural product glycosyltransferases: properties and applications. Adv Enzymol Relat Areas Mol Biol. 2009;76:55-119. PMID:18990828
  2. Qasba PK, Ramakrishnan B, Boeggeman E. Structure and function of beta -1,4-galactosyltransferase. Curr Drug Targets. 2008 Apr;9(4):292-309. PMID:18393823
  3. Jadhav SK, Patel KA, Dholakia BB, Khan BM. Structural characterization of a flavonoid glycosyltransferase from Withania somnifera. Bioinformation. 2012;8(19):943-9. doi: 10.6026/97320630008943. Epub 2012 Oct 1. PMID:23144555 doi:http://dx.doi.org/10.6026/97320630008943
  4. Yoshida A, Kobayashi K, Manya H, Taniguchi K, Kano H, Mizuno M, Inazu T, Mitsuhashi H, Takahashi S, Takeuchi M, Herrmann R, Straub V, Talim B, Voit T, Topaloglu H, Toda T, Endo T. Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev Cell. 2001 Nov;1(5):717-24. PMID:11709191
  5. Knegtel RM, Strokopytov B, Penninga D, Faber OG, Rozeboom HJ, Kalk KH, Dijkhuizen L, Dijkstra BW. Crystallographic studies of the interaction of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 with natural substrates and products. J Biol Chem. 1995 Dec 8;270(49):29256-64. PMID:7493956

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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