Glycosyltransferase
From Proteopedia
(Difference between revisions)
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**[[5v4a]] - GT + UDP – ''Streptococcus sanguinis''<br /> | **[[5v4a]] - GT + UDP – ''Streptococcus sanguinis''<br /> | ||
| - | *β-1,4-galactosyltransferase (BGT) | + | *β-1,4-galactosyltransferase 1 (BGT) |
| - | **[[1fgx]] - bBGT catalytic domain – bovine<br /> | + | **[[1fgx]] - bBGT 1 catalytic domain – bovine<br /> |
| - | **[[1pzt]] - bBGT catalytic domain (mutant) <br /> | + | **[[1pzt]], [[4krv]] - bBGT 1 catalytic domain (mutant) <br /> |
| - | **[[2fy7]] - hBGT catalytic domain (mutant) <br /> | + | **[[2fy7]] - hBGT 1 catalytic domain (mutant) <br /> |
| - | **[[3lw6]] - DmBGT catalytic domain (mutant) | + | **[[3lw6]] - DmBGT 7 catalytic domain (mutant) |
| - | *''BGT binary complexes'' | + | *''BGT 1 binary complexes'' |
| - | **[[1fr8]], [[1o0r]] - bBGT catalytic domain | + | **[[1fr8]], [[1o0r]] - bBGT 1 catalytic domain + UDP-galactose<br /> |
| - | + | ||
**[[1tw5]] - bBGT catalytic domain (mutant) + chitobiose<br /> | **[[1tw5]] - bBGT catalytic domain (mutant) + chitobiose<br /> | ||
**[[1nf5]] - bBGT + α-lactalbumin<br /> | **[[1nf5]] - bBGT + α-lactalbumin<br /> | ||
| + | **[[4l41]] - bBGT 1 (mutant) + α-lactalbumin<br /> | ||
**[[1o23]] - bBGT catalytic domain + UDP-glucose<br /> | **[[1o23]] - bBGT catalytic domain + UDP-glucose<br /> | ||
**[[1oqm]] - bBGT catalytic domain + UDP-N-acetylgalactosamine<br /> | **[[1oqm]] - bBGT catalytic domain + UDP-N-acetylgalactosamine<br /> | ||
| - | **[[2fya]] - hBGT catalytic domain (mutant) + Mn<br /> | + | **[[2fya]] - hBGT 1 catalytic domain (mutant) + Mn<br /> |
| - | **[[4ee3]], [[4ee4]], [[4ee5]], [[4eea]], [[4eeg]], [[4eem]], [[4eeo]] - hBGT catalytic domain (mutant) + polysaccharide<br /> | + | **[[4ee3]], [[4ee4]], [[4ee5]], [[4eea]], [[4eeg]], [[4eem]], [[4eeo]] - hBGT 1 catalytic domain (mutant) + polysaccharide<br /> |
| - | *''BGT ternary complexes'' | + | *''BGT 1 ternary complexes'' |
| - | **[[1nhe]], [[1nkh]] - bBGT catalytic domain + UDP + α-lactalbumin<br /> | + | **[[1nhe]], [[1nkh]] - bBGT 1 catalytic domain + UDP + α-lactalbumin<br /> |
| - | **[[1yro]] - bBGT catalytic domain (mutant) + UDP-galactose + α-lactalbumin<br /> | + | **[[1yro]] - bBGT 1 catalytic domain (mutant) + UDP-galactose + α-lactalbumin<br /> |
**[[1nwg]] - bBGT catalytic domain + N-butanoyl-glucoamine + α-lactalbumin<br /> | **[[1nwg]] - bBGT catalytic domain + N-butanoyl-glucoamine + α-lactalbumin<br /> | ||
| - | **[[1nmm]], [[1nqi]], [[1pzy]], [[1o7q]] - bBGT catalytic domain + UDP + GlcNAc<br /> | + | **[[1nmm]], [[1nqi]], [[1pzy]], [[1o7q]] - bBGT 1 catalytic domain + UDP + GlcNAc<br /> |
| - | **[[2fyb]] - hBGT catalytic domain (mutant) + Mn + UDP<br /> | + | **[[2fyb]] - hBGT 1 catalytic domain (mutant) + Mn + UDP<br /> |
| - | **[[2ae7]]- hBGT catalytic domain + UDP + pentasaccharide<br /> | + | **[[2ae7]]- hBGT 1 catalytic domain + UDP + pentasaccharide<br /> |
| - | **[[2aec]], [[2aes]], [[2agd]] - hBGT catalytic domain + UDP + GlcNAc + mannose<br /> | + | **[[2aec]], [[2aes]], [[2agd]] - hBGT 1 catalytic domain + UDP + GlcNAc + mannose<br /> |
| - | **[[2fyc]] - hBGT catalytic domain (mutant) + UDP-galactose + Ca + α-lactalbumin<br /> | + | **[[2fyc]] - hBGT 1 catalytic domain (mutant) + UDP-galactose + Ca + α-lactalbumin<br /> |
| - | **[[3ee5]] - hBGT catalytic domain (mutant) + UDP + GlcNAc-β1,3-gal-β-naphthalenemethanol<br /> | + | **[[3ee5]] - hBGT 1 catalytic domain (mutant) + UDP + GlcNAc-β1,3-gal-β-naphthalenemethanol<br /> |
| - | **[[2fyd]] - hBGT catalytic domain + UDP-GlcNAc + Mn + α-lactalbumin<br /> (mutant) + glucose<br /> | + | **[[2fyd]] - hBGT 1 catalytic domain + UDP-GlcNAc + Mn + α-lactalbumin<br /> (mutant) + glucose<br /> |
| - | **[[2ah9]] - hBGT catalytic domain + UDP + chitotriose<br /> | + | **[[2ah9]] - hBGT 1 catalytic domain + UDP + chitotriose<br /> |
| + | |||
| + | *β-1,4-galactosyltransferase 7 (BGT) | ||
| + | |||
| + | **[[3lw6]] - DmBGT 7 catalytic domain (mutant)<br /> | ||
| + | **[[1tvy]], [[1tw1]], [[4lw3]] - bBGT 7 catalytic domain (mutant) + UDP-galactose<br /> | ||
| + | **[[4irq]], [[4irp]] - bBGT 7 catalytic domain + UDP<br /> | ||
| + | **[[4lw6]] - bBGT 7 catalytic domain + xylobiose<br /> | ||
| + | **[[4m4k]] - bBGT 7 catalytic domain (mutant) + UDP-galactose + xylobiose<br /> | ||
*α-1,3-galactosyltransferase (AGT) | *α-1,3-galactosyltransferase (AGT) | ||
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**[[1r82]] - hAGT catalytic domain + UDP-galactose + inhibitor + fucose<br /> | **[[1r82]] - hAGT catalytic domain + UDP-galactose + inhibitor + fucose<br /> | ||
| - | *Fucosylglycoprotein 3-AGT (GTB) | + | *Fucosylglycoprotein 3-AGT (GTB) or histo-blood group ABO system transferase |
| - | **[[2pgv]], [[2pgy]], [[2riz]], [[2rj5]], [[1wsz]], [[2o1f]], [[2o1g]] | + | **[[2rit]], [[4kxo]] – hGTB<br /> |
| - | + | **[[2pgv]], [[2pgy]], [[2riz]], [[2rj5]], [[1wsz]], [[2o1f]], [[2o1g]], [[5cql]], [[5cqm]], [[5cqn]], [[5cqo]], [[5cqp]], [[5cmf]], [[5cmg]], [[5cmh]], [[5cmi]], [[5cmj]], [[3ioh]] – hGTB (mutant) <br /> | |
**[[2rix]] – hGTB + UDP<br /> | **[[2rix]] – hGTB + UDP<br /> | ||
| - | **[[ | + | **[[3ioj]], [[2olh]], [[5m7b]], [[5m7c]], [[5m7d]] – hGTB (mutant) + UDP<br /> |
| + | **[[4gbp]], [[4frq]], [[4fqw]], [[4fre]], [[4frh]], [[4frl]], [[4frm]], [[4fro]], [[4frp]], [[3sxa]], [[3sxb]] – hGTB + UDP-galactose<br /> | ||
| + | **[[4fra]], [[4frb]], [[4frd]], [[3zgf]], [[3zgg]], [[3v0l]], [[3v0m]], [[3v0n]], [[3v0o]], [[3ioi]] – hGTB (mutant) + UDP-galactose<br /> | ||
| + | **[[5m79]], [[5m7a]] – hGT (mutant) + UMP<br /> | ||
| + | **[[4y62]], [[4y63]], [[4y64]] - hGTB + amino acid analog<br /> | ||
| + | **[[3u0x]] – hGTB + inhibitor<br /> | ||
| + | **[[3u0y]] – hGTB (mutant) + UDP + inhibitor<br /> | ||
**[[2riy]] – hGTB + H-antigen acceptor<br /> | **[[2riy]] – hGTB + H-antigen acceptor<br /> | ||
**[[1zi4]], [[1zi5]] - hGTB + H-antigen<br /> | **[[1zi4]], [[1zi5]] - hGTB + H-antigen<br /> | ||
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**[[2rj1]], [[2rj6]] - hGTB (mutant) + UDP + H-antigen disaccharide<br /> | **[[2rj1]], [[2rj6]] - hGTB (mutant) + UDP + H-antigen disaccharide<br /> | ||
**[[2rj8]] - hGTB + UDP + H-antigen disaccharide<br /> | **[[2rj8]] - hGTB + UDP + H-antigen disaccharide<br /> | ||
| + | **[[5tjk]], [[5tjl]], [[5tjn]], [[5tjo]] - hGTB + UDP + H-antigen trisaccharide<br /> | ||
| + | **[[5c49]] - hGTB (mutant) + UDP-galactose + H-antigen <br /> | ||
**[[2rj4]] - hGTB (mutant) + UDP + ADA<br /> | **[[2rj4]] - hGTB (mutant) + UDP + ADA<br /> | ||
| - | **[[ | + | **[[5bxc]] - hGTB + UDP + deoxy-acceptor<br /> |
| - | **[[ | + | **[[5c1g]], [[5c1h]], [[4c2s]] - hGTB (mutant) + UDP + deoxy-acceptor<br /> |
| + | **[[2rj9]], [[5c36]], [[5c1l]] - hGTB + UDP-galactose + deoxy-acceptor<br /> | ||
| + | **[[2rj7]], [[5c47]], [[5c48]], [[5c38]], [[5c3a]], [[5c3b]], [[5c3d]], [[3v0p]], [[3v0q]] - hGTB (mutant) + UDP-galactose + deoxy-acceptor<br /> | ||
| + | **[[5c8r]], [[5c4b]] - hGTB + UDP-glucose + deoxy-acceptor<br /> | ||
| + | **[[5c4c]], [[5c4d]], [[5c4e]], [[5c4f]] - hGTB (mutant) + UDP-glucose + deoxy-acceptor<br /> | ||
**[[3sx3]], [[3sx5]], [[3sx7]], [[3sx8]], [[3sxc]], [[3sxd]], [[3sxe]], [[3sxg]], [[1zhj]], [[1zjo]] - hAGT catalytic domain + galactose<br /> | **[[3sx3]], [[3sx5]], [[3sx7]], [[3sx8]], [[3sxc]], [[3sxd]], [[3sxe]], [[3sxg]], [[1zhj]], [[1zjo]] - hAGT catalytic domain + galactose<br /> | ||
**[[1zi1]] - hAGT catalytic domain + lactose<br /> | **[[1zi1]] - hAGT catalytic domain + lactose<br /> | ||
Revision as of 10:29, 5 June 2018
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3D structures of glycosyltransferase
Updated on 05-June-2018
References
- ↑ Williams GJ, Thorson JS. Natural product glycosyltransferases: properties and applications. Adv Enzymol Relat Areas Mol Biol. 2009;76:55-119. PMID:18990828
- ↑ Qasba PK, Ramakrishnan B, Boeggeman E. Structure and function of beta -1,4-galactosyltransferase. Curr Drug Targets. 2008 Apr;9(4):292-309. PMID:18393823
- ↑ Jadhav SK, Patel KA, Dholakia BB, Khan BM. Structural characterization of a flavonoid glycosyltransferase from Withania somnifera. Bioinformation. 2012;8(19):943-9. doi: 10.6026/97320630008943. Epub 2012 Oct 1. PMID:23144555 doi:http://dx.doi.org/10.6026/97320630008943
- ↑ Yoshida A, Kobayashi K, Manya H, Taniguchi K, Kano H, Mizuno M, Inazu T, Mitsuhashi H, Takahashi S, Takeuchi M, Herrmann R, Straub V, Talim B, Voit T, Topaloglu H, Toda T, Endo T. Muscular dystrophy and neuronal migration disorder caused by mutations in a glycosyltransferase, POMGnT1. Dev Cell. 2001 Nov;1(5):717-24. PMID:11709191
- ↑ Knegtel RM, Strokopytov B, Penninga D, Faber OG, Rozeboom HJ, Kalk KH, Dijkhuizen L, Dijkstra BW. Crystallographic studies of the interaction of cyclodextrin glycosyltransferase from Bacillus circulans strain 251 with natural substrates and products. J Biol Chem. 1995 Dec 8;270(49):29256-64. PMID:7493956
