5o7c

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m (Protected "5o7c" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5o7c is ON HOLD until Paper Publication
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==17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal quinoline based inhibitor==
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<StructureSection load='5o7c' size='340' side='right' caption='[[5o7c]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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Authors: Bertoletti, N., Braun, F., Heine, A., Klebe, G., Marchais-Oberwinkler, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5o7c]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O7C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O7C FirstGlance]. <br>
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Description: 17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal quinoline based inhibitor
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9N2:2-(4-fluoranyl-3-oxidanyl-phenyl)carbonylquinoline-7-carbonitrile'>9N2</scene>, <scene name='pdbligand=BGC:BETA-D-GLUCOSE'>BGC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o7c OCA], [http://pdbe.org/5o7c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o7c RCSB], [http://www.ebi.ac.uk/pdbsum/5o7c PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o7c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/DHB14_HUMAN DHB14_HUMAN]] Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).<ref>PMID:17067289</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bertoletti, N]]
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[[Category: Braun, F]]
[[Category: Heine, A]]
[[Category: Heine, A]]
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[[Category: Braun, F]]
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[[Category: Klebe, G]]
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[[Category: Bertoletti, N]]
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[[Category: Marchais-Oberwinkler, S]]
[[Category: Marchais-Oberwinkler, S]]
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[[Category: Klebe, G]]
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[[Category: 17beta-hsd14]]
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[[Category: Non-steroidal inhibitor]]
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[[Category: Oxidoreductase]]
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[[Category: Quinoline based inhibitor]]

Revision as of 05:48, 6 June 2018

17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with a non-steroidal quinoline based inhibitor

5o7c, resolution 1.60Å

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