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5o57
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Solution Structure of the N-terminal Region of Dkk4== | |
| - | + | <StructureSection load='5o57' size='340' side='right' caption='[[5o57]], [[NMR_Ensembles_of_Models | 70 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5o57]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O57 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O57 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o57 OCA], [http://pdbe.org/5o57 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o57 RCSB], [http://www.ebi.ac.uk/pdbsum/5o57 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o57 ProSAT]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DKK4_HUMAN DKK4_HUMAN]] Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Barkell, A M]] | ||
| + | [[Category: Carr, M D]] | ||
| + | [[Category: Holdsworth, G]] | ||
| + | [[Category: Muskett, F W]] | ||
| + | [[Category: Patel, S]] | ||
| + | [[Category: Robinson, M K]] | ||
| + | [[Category: Waters, L C]] | ||
| + | [[Category: Cysteine-rich domain 1]] | ||
| + | [[Category: Dkk4]] | ||
| + | [[Category: Signaling protein]] | ||
| + | [[Category: Wnt signalling]] | ||
Revision as of 07:29, 14 June 2018
Solution Structure of the N-terminal Region of Dkk4
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