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5xr1

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'''Unreleased structure'''
 
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The entry 5xr1 is ON HOLD until Paper Publication
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==Structure of FLN IG21 domain in complex with C-terminal peptide of beta-2==
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<StructureSection load='5xr1' size='340' side='right' caption='[[5xr1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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Authors: Chatterjee, D., Lu, L.Z., Bhattacharjya, S.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5xr1]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XR1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XR1 FirstGlance]. <br>
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Description: Structure of FLN IG21 domain in complex with C-terminal peptide of beta-2
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xr1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xr1 OCA], [http://pdbe.org/5xr1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xr1 RCSB], [http://www.ebi.ac.uk/pdbsum/5xr1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xr1 ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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[[Category: Lu, L.Z]]
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== Disease ==
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[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Defects in ITGB2 are the cause of leukocyte adhesion deficiency type 1 (LAD1) [MIM:[http://omim.org/entry/116920 116920]]. LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.<ref>PMID:7509236</ref> <ref>PMID:1346613</ref> <ref>PMID:1968911</ref> <ref>PMID:1694220</ref> <ref>PMID:1590804</ref> <ref>PMID:1352501</ref> <ref>PMID:1347532</ref> <ref>PMID:7686755</ref> <ref>PMID:9884339</ref> <ref>PMID:20529581</ref> <ref>PMID:20549317</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/ITB2_HUMAN ITB2_HUMAN]] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.<ref>PMID:18587400</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Bhattacharjya, S]]
[[Category: Chatterjee, D]]
[[Category: Chatterjee, D]]
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[[Category: Bhattacharjya, S]]
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[[Category: Lu, L Z]]
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[[Category: Cytosolic tail]]
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[[Category: Integrin]]
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[[Category: Signaling protein]]

Revision as of 07:34, 14 June 2018

Structure of FLN IG21 domain in complex with C-terminal peptide of beta-2

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