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5o7d

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m (Protected "5o7d" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5o7d is ON HOLD
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==The X-ray structure of human R38M phosphoglycerate kinase 1 mutant==
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<StructureSection load='5o7d' size='340' side='right' caption='[[5o7d]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
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Authors: Ilari, A., Fiorillo, A., Cipollone, A., Petrosino, M.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5o7d]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5O7D OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5O7D FirstGlance]. <br>
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Description: The X-ray structure of human R38M phosphoglycerate kinase 1 mutant
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5o7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5o7d OCA], [http://pdbe.org/5o7d PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5o7d RCSB], [http://www.ebi.ac.uk/pdbsum/5o7d PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5o7d ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] Defects in PGK1 are the cause of phosphoglycerate kinase 1 deficiency (PGK1D) [MIM:[http://omim.org/entry/300653 300653]]. It is a condition with a highly variable clinical phenotype that includes hemolytic anemia, rhabdomyolysis, myopathy and neurologic involvement. Patients can express one or more of these manifestations.<ref>PMID:8673469</ref> <ref>PMID:8043870</ref> <ref>PMID:8615693</ref> <ref>PMID:9744480</ref> <ref>PMID:2001457</ref> <ref>PMID:1586722</ref> <ref>PMID:1547346</ref> <ref>PMID:6941312</ref> <ref>PMID:6933565</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/PGK1_HUMAN PGK1_HUMAN]] In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein).
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Phosphoglycerate kinase]]
[[Category: Cipollone, A]]
[[Category: Cipollone, A]]
[[Category: Fiorillo, A]]
[[Category: Fiorillo, A]]
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[[Category: Ilari, A]]
[[Category: Petrosino, M]]
[[Category: Petrosino, M]]
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[[Category: Ilari, A]]
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[[Category: Transferase]]

Revision as of 05:37, 20 June 2018

The X-ray structure of human R38M phosphoglycerate kinase 1 mutant

5o7d, resolution 1.84Å

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