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2jmh

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|LIGAND=
|LIGAND=
|ACTIVITY=
|ACTIVITY=
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|GENE= BLOT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= Blomia tropicalis])
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|GENE= BLOT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=40697 Blomia tropicalis])
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|DOMAIN=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2jmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jmh OCA], [http://www.ebi.ac.uk/pdbsum/2jmh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2jmh RCSB]</span>
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[[Category: group 5]]
[[Category: group 5]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:42:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:59:17 2008''

Revision as of 00:59, 31 March 2008

Image:2jmh.jpg


PDB ID 2jmh

Drag the structure with the mouse to rotate
Gene: BLOT5 (Blomia tropicalis)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



NMR solution structure of Blo t 5, a major mite allergen from Blomia tropicalis


Overview

Blo t 5 is the major allergen from Blomia tropicalis mites and shows strong IgE reactivity with up to 90% of asthmatic and rhinitis patients' sera. The NMR solution structure of Blo t 5 comprises three long alpha helices, forming a coiled-coil, triple-helical bundle with a left-handed twist. TROSY-NMR experiments were used to study Blo t 5 interaction with the Fab' of a specific monoclonal antibody, mAb 4A7. The mAb epitope comprises two closely spaced surfaces, I and II, connected by a sharp turn and bearing critical residues Asn46 and Lys47 on one surface, and Lys54 and Arg57 on the other. This discontinuous epitope overlaps with the human IgE epitope(s) of Blo t 5. Epitope surface II is further predicted to undergo conformational exchange in the millisecond to microsecond range. The results presented are critical for the design of a hypoallergenic Blo t 5 for efficacious immunotherapy of allergic diseases.

About this Structure

2JMH is a Single protein structure of sequence from Blomia tropicalis. Full crystallographic information is available from OCA.

Reference

Roles of structure and structural dynamics in the antibody recognition of the allergen proteins: an NMR study on Blomia tropicalis major allergen., Naik MT, Chang CF, Kuo IC, Kung CC, Yi FC, Chua KY, Huang TH, Structure. 2008 Jan;16(1):125-36. PMID:18184590

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