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6fc3
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the eIF4E-p20 complex from Saccharomyces cerevisiae== | |
| - | + | <StructureSection load='6fc3' size='340' side='right' caption='[[6fc3]], [[Resolution|resolution]] 1.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6fc3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FC3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FC3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fc3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fc3 OCA], [http://pdbe.org/6fc3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fc3 RCSB], [http://www.ebi.ac.uk/pdbsum/6fc3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fc3 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IF4E_YEAST IF4E_YEAST]] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. [[http://www.uniprot.org/uniprot/CAF20_YEAST CAF20_YEAST]] Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1/TIF4631 and EAP1 for binding to eIF4E/TIF45 and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA. Binding affinity for eIF4E/TIF45 is 10-fold less than that of eIF4G1/TIF4631. Required for induction of pseudohyphal growth in response to nitrogen limitation, probably by regulating STE12 translation.<ref>PMID:10848587</ref> <ref>PMID:12054793</ref> <ref>PMID:12406227</ref> <ref>PMID:17041186</ref> <ref>PMID:17083129</ref> <ref>PMID:9118949</ref> <ref>PMID:9707439</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Gruener, S]] | ||
| + | [[Category: Valkov, E]] | ||
| + | [[Category: Translation]] | ||
| + | [[Category: Translation translational control gene expression 4e-binding protein]] | ||
Revision as of 05:40, 27 June 2018
Crystal structure of the eIF4E-p20 complex from Saccharomyces cerevisiae
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