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2lbd
From Proteopedia
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|PDB= 2lbd |SIZE=350|CAPTION= <scene name='initialview01'>2lbd</scene>, resolution 2.06Å | |PDB= 2lbd |SIZE=350|CAPTION= <scene name='initialview01'>2lbd</scene>, resolution 2.06Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=REA:RETINOIC ACID'>REA</scene> | + | |LIGAND= <scene name='pdbligand=REA:RETINOIC+ACID'>REA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= HUMAN RAR GAMMA A CDNA (NUCLEOTIDES 946 - 1683) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= HUMAN RAR GAMMA A CDNA (NUCLEOTIDES 946 - 1683) ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lbd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lbd OCA], [http://www.ebi.ac.uk/pdbsum/2lbd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2lbd RCSB]</span> | ||
}} | }} | ||
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[[Category: Ruff, M.]] | [[Category: Ruff, M.]] | ||
[[Category: SPINE, Structural Proteomics in Europe.]] | [[Category: SPINE, Structural Proteomics in Europe.]] | ||
| - | [[Category: REA]] | ||
[[Category: active conformation]] | [[Category: active conformation]] | ||
[[Category: all-trans retinoic acid]] | [[Category: all-trans retinoic acid]] | ||
| Line 41: | Line 43: | ||
[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:03:17 2008'' |
Revision as of 01:03, 31 March 2008
| |||||||
| , resolution 2.06Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | |||||||
| Gene: | HUMAN RAR GAMMA A CDNA (NUCLEOTIDES 946 - 1683) (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO ALL-TRANS RETINOIC ACID
Overview
The 2.0-A crystal structure of the ligand-binding domain (LBD) of the human retinoic acid receptor (RAR)-gamma bound to all-trans retinoic acid reveals the ligand-binding interactions and suggests an electrostatic guidance mechanism. The overall fold is similar to that of the human RXR-alpha apo-LBD, except for the carboxy-terminal part which folds back towards the LBD core, contributing to the hydrophobic ligand pocket and 'sealing' its entry site. We propose a 'mouse trap' mechanism whereby a ligand-induced conformational transition repositions the amphipathic alpha-helix of the AF-2 activating domain and forms a transcriptionally active receptor.
About this Structure
2LBD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid., Renaud JP, Rochel N, Ruff M, Vivat V, Chambon P, Gronemeyer H, Moras D, Nature. 1995 Dec 14;378(6558):681-9. PMID:7501014
Page seeded by OCA on Mon Mar 31 04:03:17 2008
Categories: Homo sapiens | Single protein | Moras, D. | Renaud, J P. | Rochel, N. | Ruff, M. | SPINE, Structural Proteomics in Europe. | Active conformation | All-trans retinoic acid | Complex | Holo form | Ligand-binding domain | Ligand-dependent | Nuclear receptor | Retinoic acid receptor | Spine | Structural genomic | Structural proteomics in europe | Transcription regulation
