5xuy

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m (Protected "5xuy" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5xuy is ON HOLD until Paper Publication
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==Crystal structure of ATG101-ATG13HORMA==
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<StructureSection load='5xuy' size='340' side='right' caption='[[5xuy]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5xuy]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5XUY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5XUY FirstGlance]. <br>
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Description:
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5xuy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5xuy OCA], [http://pdbe.org/5xuy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5xuy RCSB], [http://www.ebi.ac.uk/pdbsum/5xuy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5xuy ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ATG13_HUMAN ATG13_HUMAN]] Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.<ref>PMID:19287211</ref> <ref>PMID:19211835</ref> <ref>PMID:19225151</ref> <ref>PMID:21855797</ref> <ref>PMID:18936157</ref> <ref>PMID:21795849</ref> [[http://www.uniprot.org/uniprot/ATGA1_HUMAN ATGA1_HUMAN]] Autophagy factor required for autophagosome formation. Stabilizes ATG13, protecting it from proteasomal degradation.<ref>PMID:19287211</ref> <ref>PMID:19597335</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Kim, B W]]
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[[Category: Song, H K]]
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[[Category: Atg101]]
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[[Category: Atg13]]
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[[Category: Autophagy]]
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[[Category: Horma]]
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[[Category: Protein binding]]

Revision as of 07:07, 4 July 2018

Crystal structure of ATG101-ATG13HORMA

5xuy, resolution 2.20Å

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