5cse
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Streptavidin-S112Y-K121E Complexed with Palladium-Containing Biotin Ligand== | |
| + | <StructureSection load='5cse' size='340' side='right' caption='[[5cse]], [[Resolution|resolution]] 1.79Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5cse]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/As_4.1583 As 4.1583]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CSE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CSE FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SVP:CHLORO{DI-TERT-BUTYL[2-({5-[(3AS,4S,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANOYL}AMINO)ETHYL]-LAMBDA~5~-PHOSPHANYL}(1-PHENYLPROP-1-ENE-1,3-DIYL-KAPPA~2~C~1~,C~3~)PALLADIUM'>SVP</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cse FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cse OCA], [http://pdbe.org/5cse PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cse RCSB], [http://www.ebi.ac.uk/pdbsum/5cse PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cse ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/SAV_STRAV SAV_STRAV]] The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin). | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Introduction of a biotinylated monophosphine palladium complex within streptavidin affords an enantioselective artificial Suzukiase. Site-directed mutagenesis allowed the optimization of the activity and the enantioselectivity of this artificial metalloenzyme. A variety of atropisomeric biaryls were produced in good yields and up to 90% ee. The hybrid catalyst described herein shows comparable TOF to the previous aqueous-asymmetric Suzuki catalysts, and excellent stability under the reaction conditions to realize higher TON through longer reaction time. | ||
| - | + | An enantioselective artificial Suzukiase based on the biotin-streptavidin technology.,Chatterjee A, Mallin H, Klehr J, Vallapurackal J, Finke AD, Vera L, Marsh M, Ward TR Chem Sci. 2016 Jan 1;7(1):673-677. doi: 10.1039/c5sc03116h. Epub 2015 Oct 19. PMID:29896353<ref>PMID:29896353</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5cse" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: As 4 1583]] | ||
[[Category: Chatterjee, A]] | [[Category: Chatterjee, A]] | ||
| - | [[Category: Finke, A | + | [[Category: Finke, A D]] |
| - | + | ||
| - | + | ||
[[Category: Marsh, M]] | [[Category: Marsh, M]] | ||
| + | [[Category: Vera, L]] | ||
| + | [[Category: Ward, T R]] | ||
| + | [[Category: Artificial metalloenzyme]] | ||
| + | [[Category: Beta barrel]] | ||
| + | [[Category: Biotin]] | ||
| + | [[Category: Biotin-binding protein]] | ||
| + | [[Category: Dimer]] | ||
| + | [[Category: Palladium]] | ||
| + | [[Category: Sugar binding protein]] | ||
| + | [[Category: Suzukiase]] | ||
Revision as of 06:01, 11 July 2018
Streptavidin-S112Y-K121E Complexed with Palladium-Containing Biotin Ligand
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