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2k2g
From Proteopedia
(Difference between revisions)
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==Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor== | ==Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor== | ||
<StructureSection load='2k2g' size='340' side='right' caption='[[2k2g]], [[NMR_Ensembles_of_Models | 17 NMR models]]' scene=''> | <StructureSection load='2k2g' size='340' side='right' caption='[[2k2g]], [[NMR_Ensembles_of_Models | 17 NMR models]]' scene=''> | ||
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMP12, HME ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MMP12, HME ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2g OCA], [http://pdbe.org/2k2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k2g RCSB], [http://www.ebi.ac.uk/pdbsum/2k2g PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2k2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k2g OCA], [http://pdbe.org/2k2g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2k2g RCSB], [http://www.ebi.ac.uk/pdbsum/2k2g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2k2g ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k2g_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k2/2k2g_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2k2g ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
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[[Category: Wilhelm, J]] | [[Category: Wilhelm, J]] | ||
[[Category: Wolfrom, S]] | [[Category: Wolfrom, S]] | ||
| + | [[Category: Calcium]] | ||
[[Category: Catalytic domain]] | [[Category: Catalytic domain]] | ||
[[Category: Extracellular matrix]] | [[Category: Extracellular matrix]] | ||
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[[Category: Metal-binding]] | [[Category: Metal-binding]] | ||
[[Category: Metalloprotease]] | [[Category: Metalloprotease]] | ||
| + | [[Category: Polymorphism]] | ||
[[Category: Protease]] | [[Category: Protease]] | ||
[[Category: Protein-ligand structure]] | [[Category: Protein-ligand structure]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
| + | [[Category: Zinc]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
Revision as of 11:15, 18 July 2018
Solution structure of the wild-type catalytic domain of human matrix metalloproteinase 12 (MMP-12) in complex with a tight-binding inhibitor
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Categories: Homo sapiens | Macrophage elastase | Dwyer, B | Li, J | Li, W | Malakian, K | Markus, M A | Tsao, D H.H | Wilhelm, J | Wolfrom, S | Calcium | Catalytic domain | Extracellular matrix | Glycoprotein | Human gene | Hydrolase | Matrix metalloproteinase | Metal-binding | Metalloprotease | Polymorphism | Protease | Protein-ligand structure | Secreted | Zinc | Zymogen
