6djc
From Proteopedia
(Difference between revisions)
m (Protected "6djc" [edit=sysop:move=sysop]) |
|||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS645== | |
| - | + | <StructureSection load='6djc' size='340' side='right' caption='[[6djc]], [[Resolution|resolution]] 1.46Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6djc]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DJC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DJC FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CF6:N,N-(decane-1,10-diyl)bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide}'>CF6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6djc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6djc OCA], [http://pdbe.org/6djc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6djc RCSB], [http://www.ebi.ac.uk/pdbsum/6djc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6djc ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Ren, C]] | [[Category: Ren, C]] | ||
| - | [[Category: Zhou, M | + | [[Category: Zhou, M M]] |
| + | [[Category: Histone acetylation]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription-inhibitor complex]] | ||
Revision as of 07:20, 25 July 2018
Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS645
| |||||||||||
