This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2oo4
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 2oo4 |SIZE=350|CAPTION= <scene name='initialview01'>2oo4</scene>, resolution 2.003Å | |PDB= 2oo4 |SIZE=350|CAPTION= <scene name='initialview01'>2oo4</scene>, resolution 2.003Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= NOTCH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= NOTCH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2oo4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2oo4 OCA], [http://www.ebi.ac.uk/pdbsum/2oo4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2oo4 RCSB]</span> | ||
}} | }} | ||
| Line 31: | Line 34: | ||
[[Category: Sanchez-Irizarry, C.]] | [[Category: Sanchez-Irizarry, C.]] | ||
[[Category: Vardar-Ulu, D.]] | [[Category: Vardar-Ulu, D.]] | ||
| - | [[Category: | + | [[Category: alpha-beta-sandwich]] |
| - | [[Category: | + | [[Category: cysteine-rich]] |
| - | [[Category: | + | [[Category: hd domain]] |
| - | [[Category: | + | [[Category: lin12 notch repeat]] |
| + | [[Category: lnr]] | ||
| + | [[Category: sea domain]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:20:38 2008'' |
Revision as of 01:20, 31 March 2008
| |||||||
| , resolution 2.003Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Gene: | NOTCH2 (Homo sapiens) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of LNR-HD (Negative Regulatory Region) from human Notch 2
Contents |
Overview
Notch receptors transmit signals between adjacent cells. Signaling is initiated when ligand binding induces metalloprotease cleavage of Notch within an extracellular negative regulatory region (NRR). We present here the X-ray structure of the human NOTCH2 NRR, which adopts an autoinhibited conformation. Extensive interdomain interactions within the NRR bury the metalloprotease site, showing that a substantial conformational movement is necessary to expose this site during activation by ligand. Leukemia-associated mutations in NOTCH1 probably release autoinhibition by destabilizing the conserved hydrophobic core of the NRR.
Disease
Known disease associated with this structure: Alagille syndrome 2 OMIM:[600275]
About this Structure
2OO4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural basis for autoinhibition of Notch., Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC, Nat Struct Mol Biol. 2007 Apr;14(4):295-300. Epub 2007 Apr 1. PMID:17401372
Page seeded by OCA on Mon Mar 31 04:20:38 2008
