5oii
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the third PDZ domain of PSD-95 protein D332G mutant: space group P21== | |
| - | + | <StructureSection load='5oii' size='340' side='right' caption='[[5oii]], [[Resolution|resolution]] 1.04Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5oii]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OII OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5OII FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5oii FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oii OCA], [http://pdbe.org/5oii PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oii RCSB], [http://www.ebi.ac.uk/pdbsum/5oii PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oii ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DLG4_HUMAN DLG4_HUMAN]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Camara-Artigas, A]] | [[Category: Camara-Artigas, A]] | ||
| + | [[Category: Pdz domain]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 21:15, 9 August 2018
Crystal Structure of the third PDZ domain of PSD-95 protein D332G mutant: space group P21
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