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6el3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Progesterone 5beta-Reductase from Arabidopsis thaliana in complex with NADP== | |
| - | + | <StructureSection load='6el3' size='340' side='right' caption='[[6el3]], [[Resolution|resolution]] 1.90Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6el3]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6EL3 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Delta(4)-3-oxosteroid_5-beta-reductase Delta(4)-3-oxosteroid 5-beta-reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.3 1.3.1.3] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6el3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6el3 OCA], [http://pdbe.org/6el3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6el3 RCSB], [http://www.ebi.ac.uk/pdbsum/6el3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6el3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/VEP1_ARATH VEP1_ARATH]] Involved in vascular strand development. Catalyzes the stereospecific conversion of progesterone to 5-beta-pregnane-3,20-dione. Can use progesterone, testosterone, 21-acetyl cortexone, 2-cyclohexenone, but-1-en-3-one, ethyl acrylate, ethylmethacrylate, cortisone and canarigenone as substrates, lower activity with 3-methyl-2-cyclohexenone and 3,5,5-trimethyl-2-cyclohexenone as substrate, and no activity with canarigenin, canarigenin digitoxoside and pregnenolone. May be involved in the formation of 5-beta phytoecdysteroids.<ref>PMID:11917087</ref> <ref>PMID:19166903</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Egerer-Sieber, C]] | ||
| + | [[Category: Muller, Y A]] | ||
| + | [[Category: Schmidt, K]] | ||
| + | [[Category: Homodimer]] | ||
| + | [[Category: Nadp binding site]] | ||
| + | [[Category: Oxidoreductase]] | ||
Revision as of 10:11, 5 September 2018
Structure of Progesterone 5beta-Reductase from Arabidopsis thaliana in complex with NADP
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