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RmlC

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<StructureSection load='2ixc' size='450' side='right' caption='Structure of RmlC complex with dTPD-rhamnose (PDB code [[2ixc]]).' scene='59/597941/Cv/1'>
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<StructureSection load='2ixc' size='350' side='right' caption='Structure of RmlC complex with dTPD-rhamnose (PDB code [[2ixc]]).' scene='59/597941/Cv/1'>
== Function ==
== Function ==
'''RmlC''' is an epimerase enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human<ref>PMID:10802738</ref>.
'''RmlC''' is an epimerase enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human<ref>PMID:10802738</ref>.

Revision as of 20:54, 14 September 2018

Structure of RmlC complex with dTPD-rhamnose (PDB code 2ixc).

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3D structures of RmlC

Updated on 14-September-2018

References

  1. ↑ Giraud MF, Leonard GA, Field RA, Berlind C, Naismith JH. RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase. Nat Struct Biol. 2000 May;7(5):398-402. PMID:10802738 doi:10.1038/75178
  2. ↑ Kantardjieff KA, Kim CY, Naranjo C, Waldo GS, Lekin T, Segelke BW, Zemla A, Park MS, Terwilliger TC, Rupp B. Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathway. Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):895-902. Epub 2004, Apr 21. PMID:15103135 doi:10.1107/S0907444904005323
  3. ↑ Dong C, Major LL, Srikannathasan V, Errey JC, Giraud MF, Lam JS, Graninger M, Messner P, McNeil MR, Field RA, Whitfield C, Naismith JH. RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation. J Mol Biol. 2007 Jan 5;365(1):146-59. Epub 2006 Sep 29. PMID:17046787 doi:http://dx.doi.org/10.1016/j.jmb.2006.09.063

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