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6dmx
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==HBZ56 in complex with KIX and c-Myb== | |
| - | + | <StructureSection load='6dmx' size='340' side='right' caption='[[6dmx]], [[Resolution|resolution]] 2.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6dmx]] is a 10 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DMX FirstGlance]. <br> | |
| - | + | </td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6dmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6dmx OCA], [http://pdbe.org/6dmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6dmx RCSB], [http://www.ebi.ac.uk/pdbsum/6dmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6dmx ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref> [[http://www.uniprot.org/uniprot/MYB_MOUSE MYB_MOUSE]] Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Histone acetyltransferase]] | ||
| + | [[Category: Stanfield, R L]] | ||
| + | [[Category: Wright, P E]] | ||
| + | [[Category: Yang, K]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Eukaryotic]] | ||
| + | [[Category: Transcription]] | ||
| + | [[Category: Transcription coactivator]] | ||
| + | [[Category: Transcription factor]] | ||
| + | [[Category: Viral]] | ||
Revision as of 19:50, 19 September 2018
HBZ56 in complex with KIX and c-Myb
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