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2vpe
From Proteopedia
(Difference between revisions)
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| - | == | + | |
| + | ==Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex== | ||
<StructureSection load='2vpe' size='340' side='right' caption='[[2vpe]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2vpe' size='340' side='right' caption='[[2vpe]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| Line 6: | Line 7: | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vp7|2vp7]], [[2vpb|2vpb]], [[2vpd|2vpd]], [[2vpg|2vpg]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2vp7|2vp7]], [[2vpb|2vpb]], [[2vpd|2vpd]], [[2vpg|2vpg]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpe OCA], [http://pdbe.org/2vpe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vpe RCSB], [http://www.ebi.ac.uk/pdbsum/2vpe PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vpe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vpe OCA], [http://pdbe.org/2vpe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vpe RCSB], [http://www.ebi.ac.uk/pdbsum/2vpe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vpe ProSAT]</span></td></tr> |
</table> | </table> | ||
| - | == Disease == | ||
| - | [[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Note=A chromosomal aberration involving BCL9 is found in a patient with precusor B-cell acute lymphoblastic leukemia (ALL). Translocation t(1;14)(q21;q32). This translocation leaves the coding region intact, but may have pathogenic effects due to alterations in the expression level of BCL9. Several cases of translocations within the 3'-UTR of BCL9 have been found in B-cell malignancies. | ||
| - | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/BCL9_HUMAN BCL9_HUMAN]] Involved in signal transduction through the Wnt pathway. Promotes beta-catenin's transcriptional activity (By similarity).<ref>PMID:11955446</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vpe_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/2vpe_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
| Line 45: | Line 42: | ||
[[Category: Sanchez-Barrena, M J]] | [[Category: Sanchez-Barrena, M J]] | ||
[[Category: Bcl9 hd1 domain]] | [[Category: Bcl9 hd1 domain]] | ||
| + | [[Category: Chromosomal rearrangement]] | ||
[[Category: Gene regulation]] | [[Category: Gene regulation]] | ||
[[Category: Histone h3k4me2]] | [[Category: Histone h3k4me2]] | ||
| Line 55: | Line 53: | ||
[[Category: Wnt signaling complex]] | [[Category: Wnt signaling complex]] | ||
[[Category: Wnt signaling pathway]] | [[Category: Wnt signaling pathway]] | ||
| + | [[Category: Zinc]] | ||
[[Category: Zinc-finger]] | [[Category: Zinc-finger]] | ||
Revision as of 21:01, 19 September 2018
Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex
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Categories: Human | Bienz, M | Evans, P | Fiedler, M | Mieszczanek, J | Muller, J | Nekrasov, M | Rybin, V | Sanchez-Barrena, M J | Bcl9 hd1 domain | Chromosomal rearrangement | Gene regulation | Histone h3k4me2 | Hpygo1 phd domain | Metal-binding | Nucleus | Phosphoprotein | Proto-oncogene | Signaling protein | Wnt signaling complex | Wnt signaling pathway | Zinc | Zinc-finger
