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2vt0
From Proteopedia
(Difference between revisions)
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==X-ray structure of a conjugate with conduritol-beta-epoxide of acid-beta-glucosidase overexpressed in cultured plant cells== | ==X-ray structure of a conjugate with conduritol-beta-epoxide of acid-beta-glucosidase overexpressed in cultured plant cells== | ||
<StructureSection load='2vt0' size='340' side='right' caption='[[2vt0]], [[Resolution|resolution]] 2.15Å' scene=''> | <StructureSection load='2vt0' size='340' side='right' caption='[[2vt0]], [[Resolution|resolution]] 2.15Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vt0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VT0 FirstGlance]. <br> | <table><tr><td colspan='2'>[[2vt0]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VT0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VT0 FirstGlance]. <br> | ||
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBU:(1R,2R,3S,4S,5S,6S)-CYCLOHEXANE-1,2,3,4,5,6-HEXOL'>CBU | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CBU:(1R,2R,3S,4S,5S,6S)-CYCLOHEXANE-1,2,3,4,5,6-HEXOL'>CBU</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosylceramidase Glucosylceramidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.45 3.2.1.45] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucosylceramidase Glucosylceramidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.45 3.2.1.45] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vt0 OCA], [http://pdbe.org/2vt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vt0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vt0 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vt0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vt0 OCA], [http://pdbe.org/2vt0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vt0 RCSB], [http://www.ebi.ac.uk/pdbsum/2vt0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vt0 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vt/2vt0_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vt/2vt0_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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[[Category: Sussman, J L]] | [[Category: Sussman, J L]] | ||
[[Category: Alternative initiation]] | [[Category: Alternative initiation]] | ||
| + | [[Category: Alternative splicing]] | ||
[[Category: Cerezyme]] | [[Category: Cerezyme]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
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[[Category: Lysosome]] | [[Category: Lysosome]] | ||
[[Category: Membrane]] | [[Category: Membrane]] | ||
| + | [[Category: Pharmaceutical]] | ||
| + | [[Category: Polymorphism]] | ||
[[Category: Sphingolipid metabolism]] | [[Category: Sphingolipid metabolism]] | ||
[[Category: Structural genomic]] | [[Category: Structural genomic]] | ||
Revision as of 21:16, 19 September 2018
X-ray structure of a conjugate with conduritol-beta-epoxide of acid-beta-glucosidase overexpressed in cultured plant cells
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Categories: Glucosylceramidase | Human | Aviezer, D | Brumshtein, B | Futerman, A H | Greenblatt, H M | Shaaltiel, Y | Silman, I | Sussman, J L | Alternative initiation | Alternative splicing | Cerezyme | Disease mutation | Gaucher disease | Glucocerebrosidase | Glucosidase | Glycoprotein | Glycosidase | Hydrolase | ISPC, Israel Structural Proteomics Center | Lipid metabolism | Lysosome | Membrane | Pharmaceutical | Polymorphism | Sphingolipid metabolism | Structural genomic
