Single-stranded DNA-binding protein
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| - | <StructureSection load='1eqq' size=' | + | <StructureSection load='1eqq' size='350' side='right' scene='' caption='E. coli SSB complex with ssDNA (stick model) and UMP [[1eqq]]'> |
'''Single-stranded DNA-binding protein''' (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities<ref>PMID:22976174</ref>.<br /> | '''Single-stranded DNA-binding protein''' (SSB) binds to single-stranded regions of DNA (ssDNA) to protect it from annealing, prevention of secondary structure formation and digestion. SSB binds to DNA in a sequence-independent manner. The binding of SSB enables processes like replication, DNA repair and recombination to occur. SSB can form complexes with specific genome maintenance proteins helping their activities<ref>PMID:22976174</ref>.<br /> | ||
* '''Viral SSB proteins''' are monomeric.<br /> | * '''Viral SSB proteins''' are monomeric.<br /> | ||
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**[[4gs3]] – SSB N terminal – ''Thermoanaerobacter tengcongensis''<br /> | **[[4gs3]] – SSB N terminal – ''Thermoanaerobacter tengcongensis''<br /> | ||
**[[3dm3]] – SSB A domain – ''Methancaldococcus jannaschii''<br /> | **[[3dm3]] – SSB A domain – ''Methancaldococcus jannaschii''<br /> | ||
| - | **[[5xgt]] – SSB N-terminal – ''Staphylococcus aureus''<br /> | + | **[[5xgt]], [[5yyu]] – SSB N-terminal – ''Staphylococcus aureus''<br /> |
| - | **[[5m1x]] – ySSB N-OB domain (mutant) | + | **[[6cqk]], [[6cqm]], [[6cqo]] – ySSB N terminal domain - yeast<br /> |
| + | **[[5m1x]] – ySSB N-OB domain (mutant)<br /> | ||
**[[5d8e]], [[5d8f]] – hSSB residues 1-109 (mutant) - human<br /> | **[[5d8e]], [[5d8f]] – hSSB residues 1-109 (mutant) - human<br /> | ||
Revision as of 18:36, 20 September 2018
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3D Structures of single-stranded DNA-binding protein
Updated on 20-September-2018
References
- ↑ Marceau AH. Functions of single-strand DNA-binding proteins in DNA replication, recombination, and repair. Methods Mol Biol. 2012;922:1-21. doi: 10.1007/978-1-62703-032-8_1. PMID:22976174 doi:http://dx.doi.org/10.1007/978-1-62703-032-8_1