DNA methyltransferase

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Line 77: Line 77:
**[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + SAH<br />
**[[4u7p]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + SAH<br />
**[[6f57]], [[5yx2]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br />
**[[6f57]], [[5yx2]] - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br />
-
**[[6f57]] - h-cytosine DNMT 3A residues 439-723 + h-cytosine DNMT 3-like residues 178-379 + DNA + SAH + pyrimidine derivative<br />
 
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + histone 3.3 + SAH<br />
**[[4u7t]] - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3-like residues 178-379 + histone 3.3 + SAH<br />
**[[3av4]], [[1khc]] - m-cytosine DNMT – mouse<br />
**[[3av4]], [[1khc]] - m-cytosine DNMT – mouse<br />
Line 107: Line 106:
**[[4fsx]] – c-cytosine DNMT + SAH – corn<br />
**[[4fsx]] – c-cytosine DNMT + SAH – corn<br />
**[[4ft2]], [[4ft4]] – c-cytosine DNMT + histone H3 peptide<br />
**[[4ft2]], [[4ft4]] – c-cytosine DNMT + histone H3 peptide<br />
-
**[[4h0n]] - cytosine DNMT (mutant) – ''Spodoptera frugiperda''
+
**[[4h0n]] - cytosine DNMT (mutant) – ''Spodoptera frugiperda''<br/>
 +
**[[6fdf]] - cytosine DNMT2 + SAH – fission yeast<br/>
*Methyladenine DNMT
*Methyladenine DNMT

Revision as of 17:36, 27 September 2018

Adenine DNMT complex with SAM and Cl- ion (PDB code 1nw5).

Drag the structure with the mouse to rotate

3D Structures of DNA methyltransferase

Updated on 27-September-2018

References

  1. Kaina B, Christmann M, Naumann S, Roos WP. MGMT: key node in the battle against genotoxicity, carcinogenicity and apoptosis induced by alkylating agents. DNA Repair (Amst). 2007 Aug 1;6(8):1079-99. Epub 2007 May 7. PMID:17485253 doi:http://dx.doi.org/10.1016/j.dnarep.2007.03.008
  2. Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG. The DNA (cytosine-5) methyltransferases. Nucleic Acids Res. 1994 Jan 11;22(1):1-10. PMID:8127644
  3. Thomas CB, Scavetta RD, Gumport RI, Churchill ME. Structures of liganded and unliganded RsrI N6-adenine DNA methyltransferase: a distinct orientation for active cofactor binding. J Biol Chem. 2003 Jul 11;278(28):26094-101. Epub 2003 May 4. PMID:12732637 doi:http://dx.doi.org/10.1074/jbc.M303751200
  4. Sankpal UT, Rao DN. Structure, function, and mechanism of HhaI DNA methyltransferases. Crit Rev Biochem Mol Biol. 2002;37(3):167-97. PMID:12139442 doi:http://dx.doi.org/10.1080/10409230290771492

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Michal Harel, Alexander Berchansky

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