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| - | ==Crystal structure of RFXANK ankyrin repeats in complex with RFX7==
| + | #REDIRECT [[6mew]] This PDB entry is obsolete and replaced by 6mew |
| - | <StructureSection load='4qqm' size='340' side='right' caption='[[4qqm]], [[Resolution|resolution]] 1.78Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[4qqm]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QQM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QQM FirstGlance]. <br>
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| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene><br>
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| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qqm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qqm RCSB], [http://www.ebi.ac.uk/pdbsum/4qqm PDBsum]</span></td></tr>
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| - | <table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN]] Immunodeficiency by defective expression of HLA class 2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:9806546</ref> <ref>PMID:10072068</ref> <ref>PMID:10725724</ref>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/RFXK_HUMAN RFXK_HUMAN]] Activates transcription from class II MHC promoters. Activation requires the activity of the MHC class II transactivator (MHC2TA). May regulate other genes in the cell. RFX binds the X1 box of MHC-II promoters. Isoform RFX-B-delta5 is not involved in the positive regulation of MHC class II genes.
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Arrowsmith, C H.]]
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| - | [[Category: Bountra, C.]]
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| - | [[Category: Dong, A.]]
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| - | [[Category: Edwards, A M.]]
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| - | [[Category: Li, Y.]]
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| - | [[Category: Min, J.]]
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| - | [[Category: SGC, Structural Genomics Consortium.]]
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| - | [[Category: Tempel, W.]]
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| - | [[Category: Xu, C.]]
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| - | [[Category: Ankyrin repeat]]
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| - | [[Category: Dna binding protein]]
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| - | [[Category: Sgc]]
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| - | [[Category: Structural genomic]]
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| - | [[Category: Structural genomics consortium]]
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