This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6gbi
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6gbi is ON HOLD Authors: Description: Category: Unreleased Structures) |
|||
| (2 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Wnt signalling== | |
| + | <StructureSection load='6gbi' size='340' side='right' caption='[[6gbi]], [[Resolution|resolution]] 1.25Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6gbi]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6GBI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6GBI FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LYPD6, UNQ3023/PRO9821 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6gbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6gbi OCA], [http://pdbe.org/6gbi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6gbi RCSB], [http://www.ebi.ac.uk/pdbsum/6gbi PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6gbi ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LYPD6_HUMAN LYPD6_HUMAN]] Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain. Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity).[UniProtKB:Q66IA6]<ref>PMID:27344019</ref> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | LYPD6 is a Wnt signaling enhancer that promotes phosphorylation of the Wnt co-receptor LRP6 (low-density lipoprotein receptor-related protein 6). It also binds the nicotinic acetylcholine receptor (nAChR). We report here the 1.25 A resolution structure of the LYPD6 extracellular Ly6/uPAR (LU) domain and map its interaction with LRP6 by mutagenesis and surface plasmon resonance (SPR). The LYPD6LU structure reveals a "tri-fingered protein domain" fold with the middle fingertip of the bearing a "NxI" motif, a tripeptide motif associated with LRP5/6 binding by Wnt inhibitors. Of the Ly6 protein family members, only LYPD6 has an NxI motif. Since mutations in the LYPD6 NxI motif abolish or severely reduce interaction with LRP6, our results indicate its key role in the interaction of LYPD6 with LRP6. This article is protected by copyright. All rights reserved. | ||
| - | + | Structure of the Wnt signaling enhancer LYPD6 and its interactions with the Wnt co-receptor LRP6.,Zhao Y, Ren J, Lu W, Harlos K, Jones EY FEBS Lett. 2018 Aug 1. doi: 10.1002/1873-3468.13212. PMID:30069874<ref>PMID:30069874</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 6gbi" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Human]] | ||
| + | [[Category: Jones, E Y]] | ||
| + | [[Category: Zhao, Y]] | ||
| + | [[Category: Structural protein]] | ||
| + | [[Category: Wnt]] | ||
Current revision
Wnt signalling
| |||||||||||
Categories: Human | Jones, E Y | Zhao, Y | Structural protein | Wnt
