Ubiquitin protein ligase

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Line 89: Line 89:
**[[2xp0]] – hUPL C terminal <br />
**[[2xp0]] – hUPL C terminal <br />
-
*'''Ubiquitin protein ligase Cbl'''
+
*'''Ubiquitin protein ligase Cbl''' Domains:Tyr kinase-binding (TKB) 25-351;RING 358-437;WW3 399-432;catalytic 495-852; UBA 924-973-432
 +
**[[2y1m]] – hUPL <br />
**[[5j3x]] – hUPL (mutant)<br />
**[[5j3x]] – hUPL (mutant)<br />
-
**[[2y1m]] – hUPL - human<br />
 
**[[1d5f]] – hUPL catalytic domain <br />
**[[1d5f]] – hUPL catalytic domain <br />
**[[2dk3]] – hUPL catalytic domain - NMR<br />
**[[2dk3]] – hUPL catalytic domain - NMR<br />
**[[1yiu]] – hUPL WW3 domain - NMR<br />
**[[1yiu]] – hUPL WW3 domain - NMR<br />
**[[2k4d]] – hUPL RING domain<br />
**[[2k4d]] – hUPL RING domain<br />
 +
**[[2ldr]] – hUPL RING domain - NMR <br />
**[[2oo9]], [[2ooa]], [[2oob]] – hUPL UBA domain <br />
**[[2oo9]], [[2ooa]], [[2oob]] – hUPL UBA domain <br />
**[[2do6]], [[2ekk]], [[2jnh]], [[2juj]] – hUPL UBA domain - NMR<br />
**[[2do6]], [[2ekk]], [[2jnh]], [[2juj]] – hUPL UBA domain - NMR<br />
**[[3vgo]] – hUPL N terminal <br />
**[[3vgo]] – hUPL N terminal <br />
**[[2kr1]] – hUPL N terminal - NMR <br />
**[[2kr1]] – hUPL N terminal - NMR <br />
-
**[[2ldr]] – hUPL helix-ring domain - NMR <br />
 
**[[2d9s]] – mUPL UBA domain – mouse - NMR<br />
**[[2d9s]] – mUPL UBA domain – mouse - NMR<br />
 +
**[[6bk5]] – UPL - ''Salpingoeca rosetta'' <br />
*Ubiquitin protein ligase Cbl complex
*Ubiquitin protein ligase Cbl complex
Line 109: Line 110:
**[[3bum]], [[3bun]], [[3buo]], [[3buw]], [[3bux]], [[3ob1]], [[3ob2]], [[3rlf]], [[3pfv]], [[2k4d]], [[4gpl]] – hUPL TKB domain + peptide <br />
**[[3bum]], [[3bun]], [[3buo]], [[3buw]], [[3bux]], [[3ob1]], [[3ob2]], [[3rlf]], [[3pfv]], [[2k4d]], [[4gpl]] – hUPL TKB domain + peptide <br />
**[[2y1n]] – hUPL residues 47-435 + ZAP peptide <br />
**[[2y1n]] – hUPL residues 47-435 + ZAP peptide <br />
 +
**[[5o76]] – hUPL residues 47-435 (mutant) + ZAP peptide <br />
**[[4a4b]], [[4a4c]] – hUPL TKB domain (mutant) + ZAP peptide + ubiquitin conjugating enzyme E2 <br />
**[[4a4b]], [[4a4c]] – hUPL TKB domain (mutant) + ZAP peptide + ubiquitin conjugating enzyme E2 <br />
**[[1c4z]] – hUPL catalytic domain + ubiquitin conjugating enzyme E2 <br />
**[[1c4z]] – hUPL catalytic domain + ubiquitin conjugating enzyme E2 <br />
-
**[[4a49]] – hUPL residues 354-435 + ubiquitin conjugating enzyme E2 <br />
+
**[[4a49]] – hUPL RING domain + ubiquitin conjugating enzyme E2 <br />
**[[5axi]] – mUPL-B TKB domain + cblin <br />
**[[5axi]] – mUPL-B TKB domain + cblin <br />
Line 125: Line 127:
**[[5igo]] – AtUPL + Trib1 peptide - ''Arabidopsis thaliana'' <br />
**[[5igo]] – AtUPL + Trib1 peptide - ''Arabidopsis thaliana'' <br />
 +
**[[5kwn]] – AtUPL + HY5 peptide <br />
**[[5igq]] – hUPL + Trib1 peptide <br />
**[[5igq]] – hUPL + Trib1 peptide <br />
**[[5hqg]] – hUPL <br />
**[[5hqg]] – hUPL <br />
Line 166: Line 169:
**[[3zqs]] – hUPL residues 109-294<br />
**[[3zqs]] – hUPL residues 109-294<br />
**[[4ccg]] – hUPL RING domain + E2 T<br />
**[[4ccg]] – hUPL RING domain + E2 T<br />
 +
**[[3k1l]] – UPL - ''Drosophila melanogaster''<br />
*'''Ubiquitin protein ligase HAKAI'''
*'''Ubiquitin protein ligase HAKAI'''
**[[3vk6]] – mUPL phosphotyrosine-binding domain<br />
**[[3vk6]] – mUPL phosphotyrosine-binding domain<br />
 +
**[[2mq1]] – mUPL phosphotyrosine-binding domain - NMR<br />
-
*'''Ubiquitin protein ligase HECTD1'''
+
*'''Ubiquitin protein ligase HECTD1''' Domains: CHP 1268-1340;helical bundle 1879-1966;
**[[3dkm]] – hUPL CPH domain <br />
**[[3dkm]] – hUPL CPH domain <br />
 +
**[[2dk3]] – hUPL CHP domain - NMR<br />
**[[2lc3]] – hUPL helical bundle domain - NMR<br />
**[[2lc3]] – hUPL helical bundle domain - NMR<br />
-
*'''Ubiquitin protein ligase HECW'''
+
*'''Ubiquitin protein ligase HECW1'''
**[[3l4h]] – hUPL WW2 and helical box domains <br />
**[[3l4h]] – hUPL WW2 and helical box domains <br />
 +
 +
*'''Ubiquitin protein ligase HECW2'''
 +
**[[2lfe]] – hUPL N terminal - NMR<br />
**[[2lfe]] – hUPL N terminal - NMR<br />

Revision as of 19:24, 3 October 2018

Human UPL HOIP (magenta) complex with ubiquitin (green), imidazole and Zn+2 ion (grey) 4ljo

Drag the structure with the mouse to rotate

3D Structures of ubiquitin protein ligase

Updated on 03-October-2018

References

  1. ↑ Ardley HC, Robinson PA. E3 ubiquitin ligases. Essays Biochem. 2005;41:15-30. PMID:16250895 doi:http://dx.doi.org/10.1042/EB0410015
  2. ↑ Sakemi R, Yano H, Ogasawara S, Akiba J, Nakashima O, Fukahori S, Sata M, Kojiro M. X-linked inhibitor of apoptosis (XIAP) and XIAP-associated factor-1 expressions and their relationship to apoptosis in human hepatocellular carcinoma and non-cancerous liver tissues. Oncol Rep. 2007 Jul;18(1):65-70. PMID:17549347
  3. ↑ Aguilar C, Lenoir C, Lambert N, Begue B, Brousse N, Canioni D, Berrebi D, Roy M, Gerart S, Chapel H, Schwerd T, Siproudhis L, Schappi M, Al-Ahmari A, Mori M, Yamaide A, Galicier L, Neven B, Routes J, Uhlig HH, Koletzko S, Patel S, Kanegane H, Picard C, Fischer A, Bensussan NC, Ruemmele F, Hugot JP, Latour S. Characterization of Crohn disease in X-linked inhibitor of apoptosis-deficient male patients and female symptomatic carriers. J Allergy Clin Immunol. 2014 Nov;134(5):1131-41.e9. doi:, 10.1016/j.jaci.2014.04.031. Epub 2014 Jun 15. PMID:24942515 doi:http://dx.doi.org/10.1016/j.jaci.2014.04.031
  4. ↑ Ardley HC, Robinson PA. The role of ubiquitin-protein ligases in neurodegenerative disease. Neurodegener Dis. 2004;1(2-3):71-87. PMID:16908979 doi:http://dx.doi.org/10.1159/000080048
  5. ↑ Xu G, Jiang X, Jaffrey SR. A mental retardation-linked nonsense mutation in cereblon is rescued by proteasome inhibition. J Biol Chem. 2013 Oct 11;288(41):29573-85. doi: 10.1074/jbc.M113.472092. Epub, 2013 Aug 27. PMID:23983124 doi:http://dx.doi.org/10.1074/jbc.M113.472092
  6. ↑ Lu G, Middleton RE, Sun H, Naniong M, Ott CJ, Mitsiades CS, Wong KK, Bradner JE, Kaelin WG Jr. The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins. Science. 2014 Jan 17;343(6168):305-9. doi: 10.1126/science.1244917. Epub 2013 Nov, 29. PMID:24292623 doi:http://dx.doi.org/10.1126/science.1244917
  7. ↑ Stieglitz B, Rana RR, Koliopoulos MG, Morris-Davies AC, Schaeffer V, Christodoulou E, Howell S, Brown NR, Dikic I, Rittinger K. Structural basis for ligase-specific conjugation of linear ubiquitin chains by HOIP. Nature. 2013 Oct 20. doi: 10.1038/nature12638. PMID:24141947 doi:http://dx.doi.org/10.1038/nature12638
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