2qx5
From Proteopedia
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|PDB= 2qx5 |SIZE=350|CAPTION= <scene name='initialview01'>2qx5</scene>, resolution 2.5Å | |PDB= 2qx5 |SIZE=350|CAPTION= <scene name='initialview01'>2qx5</scene>, resolution 2.5Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=CL:CHLORIDE ION'>CL</scene> | + | |LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= NIC96 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | |GENE= NIC96 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qx5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qx5 OCA], [http://www.ebi.ac.uk/pdbsum/2qx5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qx5 RCSB]</span> | ||
}} | }} | ||
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[[Category: Jeudy, S.]] | [[Category: Jeudy, S.]] | ||
[[Category: Schwartz, T U.]] | [[Category: Schwartz, T U.]] | ||
| - | [[Category: CL]] | ||
[[Category: mrna transport]] | [[Category: mrna transport]] | ||
[[Category: nuclear pore complex]] | [[Category: nuclear pore complex]] | ||
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[[Category: transport protein]] | [[Category: transport protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:54:26 2008'' |
Revision as of 01:54, 31 March 2008
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| , resolution 2.5Å | |||||||
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| Ligands: | |||||||
| Gene: | NIC96 (Saccharomyces cerevisiae) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of nucleoporin Nic96
Overview
The nuclear pore complex (NPC) is an elaborate protein machine that mediates macromolecular transport across the nuclear envelope in all eukaryotes. The NPC is formed by nucleoporins that assemble in multiple copies around an 8-fold symmetry axis. Homology modeling suggests that most architectural nucleoporins are composed of simple beta-propeller and alpha-helical repeat domains. Here we present the crystal structure of Nic96, the Nup93 homolog in Saccharomyces cerevisiae, one of the major components of the NPC. This is the first structure of an alpha-helical nucleoporin domain. The protein folds into an elongated, mostly alpha-helical structure. Characteristically, non-canonical architectural features define the Nic96 structure. Sequence conservation among Nup93 homologs across all eukaryotes strongly suggests that the distinct topology is evolutionarily well maintained. We propose that the unique Nic96/Nup93 fold has a conserved function in all eukaryotes.
About this Structure
2QX5 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
Crystal structure of nucleoporin Nic96 reveals a novel, intricate helical domain architecture., Jeudy S, Schwartz TU, J Biol Chem. 2007 Nov 30;282(48):34904-12. Epub 2007 Sep 25. PMID:17897938
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