This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6a5w

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 6a5w is ON HOLD until Paper Publication
+
==FXR-LBD with HNC143 and SRC1==
-
 
+
<StructureSection load='6a5w' size='340' side='right' caption='[[6a5w]], [[Resolution|resolution]] 2.88&Aring;' scene=''>
-
Authors: Wang, N., Liu, J.
+
== Structural highlights ==
-
 
+
<table><tr><td colspan='2'>[[6a5w]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6A5W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6A5W FirstGlance]. <br>
-
Description: FXR-LBD with HNC143 and SRC1
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9R0:2-[2-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-6-azaspiro[3.4]octan-6-yl]-1,3-benzothiazole-6-carboxylic+acid'>9R0</scene></td></tr>
-
[[Category: Unreleased Structures]]
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6a5w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6a5w OCA], [http://pdbe.org/6a5w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6a5w RCSB], [http://www.ebi.ac.uk/pdbsum/6a5w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6a5w ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN]] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Liu, J]]
[[Category: Liu, J]]
[[Category: Wang, N]]
[[Category: Wang, N]]
 +
[[Category: Agonist]]
 +
[[Category: Coactivator]]
 +
[[Category: Complex]]
 +
[[Category: Nuclear receptor]]
 +
[[Category: Transcription]]

Revision as of 08:01, 10 October 2018

FXR-LBD with HNC143 and SRC1

6a5w, resolution 2.88Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6a5w"
Personal tools