This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5z4m
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Structure of TailorD343A with bound UTP and Mg== | |
| - | + | <StructureSection load='5z4m' size='340' side='right' caption='[[5z4m]], [[Resolution|resolution]] 1.74Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5z4m]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Z4M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5Z4M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr> | |
| - | [[Category: | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA_uridylyltransferase RNA uridylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.52 2.7.7.52] </span></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5z4m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5z4m OCA], [http://pdbe.org/5z4m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5z4m RCSB], [http://www.ebi.ac.uk/pdbsum/5z4m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5z4m ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TUTT_DROME TUTT_DROME]] Uridylyltransferase which mediates terminal uridylation of miRNAs, leading to their degradation. Has high specificity for splicing-derived miRNAs (mirtrons) and other miRNA substrates containing a 3'-G terminal nucleotide. Appears to be a major suppressor of mirtron biogenesis.<ref>PMID:26145174</ref> <ref>PMID:26145176</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: RNA uridylyltransferase]] | ||
[[Category: Cheng, L]] | [[Category: Cheng, L]] | ||
| - | [[Category: Yu, H]] | ||
[[Category: Gong, Q]] | [[Category: Gong, Q]] | ||
| + | [[Category: Jiang, Y]] | ||
| + | [[Category: Li, F]] | ||
[[Category: Shi, Y]] | [[Category: Shi, Y]] | ||
| - | [[Category: Jiang, Y]] | ||
[[Category: Xie, C]] | [[Category: Xie, C]] | ||
| - | [[Category: | + | [[Category: Yu, H]] |
| + | [[Category: Terminal uridylyltransferase]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 06:45, 31 October 2018
Structure of TailorD343A with bound UTP and Mg
| |||||||||||
