2-oxoisovalerate dehydrogenase
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''2-oxoisovalerate dehydrogenase''' <ref>PMID:21638687</ref> == Dis...) |
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Function == | == Function == | ||
| - | '''2-oxoisovalerate dehydrogenase''' | + | '''2-oxoisovalerate dehydrogenase''' (OIVD) is part of a multienzyme complex metabolizing pyruvate, 2-oxogluterate and branched-chain 2-oxo acids. The active site of OIVD contains the cofactor thiamin diphosphate (TDP) |
| - | <ref>PMID: | + | <ref>PMID:10426958</ref>. |
== Disease == | == Disease == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
| - | [[2bp7]] - OIVD | + | [[2bp7]] - OIVD α+β subunits - ''Pseudomonas putida''<br /> |
| - | [[1v1r]] - hOIVD | + | [[1v1r]] - hOIVD α+β subunits - human<br /> |
| - | [[1u5b]], [[1x80]], [[1ols]] - hOIVD | + | [[1u5b]], [[1x80]], [[1ols]] - hOIVD α+β subunits + TDP <br /> |
| - | [[1x7x]], [[1x7w]], [[1x7y]], [[1x7z]], [[2j9f]], [[1olu]], [[2bfb]], [[2bfd]], [[2bfe]], [[1v11]] - hOIVD | + | [[1x7x]], [[1x7w]], [[1x7y]], [[1x7z]], [[2j9f]], [[1olu]], [[2bfb]], [[2bfd]], [[2bfe]], [[1v11]] - hOIVD α (mutant)+ β subunits + TDP derivative<br /> |
| - | [[1olx]] - hOIVD | + | [[1olx]] - hOIVD α+β (mutant) subunits + TDP<br /> |
| - | [[1wci]] - hOIVD | + | [[1wci]] - hOIVD α+β subunits + thiamine derivative<br /> |
| - | [[2bfe]] - hOIVD | + | [[2bfe]] - hOIVD α+β subunits + pyrimidine derivative<br /> |
| - | [[2bfc]] - hOIVD | + | [[2bfc]] - hOIVD α (mutant)+ β subunits + pyrimidine derivative<br /> |
| - | [[1v16]] - hOIVD | + | [[1v16]] - hOIVD α+β subunits + TDP + benzamidine<br /> |
| - | [[1v1m]] - hOIVD | + | [[1v1m]] - hOIVD α (mutant)+ β subunits + TDP + benzamidine<br /> |
| - | [[2bew]], [[2beu]], [[2bev]] - hOIVD | + | [[2bew]], [[2beu]], [[2bev]] - hOIVD α+β subunits + TDP derivative + peptide<br /> |
== References == | == References == | ||
Revision as of 07:44, 6 November 2018
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3D structures of 2-oxoisovalerate dehydrogenase
Updated on 06-November-2018
2bp7 - OIVD α+β subunits - Pseudomonas putida
1v1r - hOIVD α+β subunits - human
1u5b, 1x80, 1ols - hOIVD α+β subunits + TDP
1x7x, 1x7w, 1x7y, 1x7z, 2j9f, 1olu, 2bfb, 2bfd, 2bfe, 1v11 - hOIVD α (mutant)+ β subunits + TDP derivative
1olx - hOIVD α+β (mutant) subunits + TDP
1wci - hOIVD α+β subunits + thiamine derivative
2bfe - hOIVD α+β subunits + pyrimidine derivative
2bfc - hOIVD α (mutant)+ β subunits + pyrimidine derivative
1v16 - hOIVD α+β subunits + TDP + benzamidine
1v1m - hOIVD α (mutant)+ β subunits + TDP + benzamidine
2bew, 2beu, 2bev - hOIVD α+β subunits + TDP derivative + peptide
References
- ↑ Aevarsson A, Seger K, Turley S, Sokatch JR, Hol WG. Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes. Nat Struct Biol. 1999 Aug;6(8):785-92. PMID:10426958 doi:10.1038/11563
