Sialidase
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | ''' | + | '''Sialidase''' is a neuraminidase which cleaves terminal sialic acid from a variety of natural substances <ref>PMID:12374200</ref>. '''Trans-sialidase''' is a modified sialidase which has transglycosidase activity and transfers sialic acid from host glycoconjugates to β-galactose on a parasite surface<ref>PMID:15588836</ref>, <ref>PMID:8405811</ref>. |
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
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| + | ''Trypanosoma cruzi'' trans-sialidase is a drug target agains Chagas Disease<ref>PMID:24144418</ref>. | ||
== Structural highlights == | == Structural highlights == | ||
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**[[3b69]], [[1ms0]], [[1ms1]], [[1ms5]], [[1ms8]] - TcSal (mutant) + neuraminic acid derivative<br /> | **[[3b69]], [[1ms0]], [[1ms1]], [[1ms5]], [[1ms8]] - TcSal (mutant) + neuraminic acid derivative<br /> | ||
**[[3opz]] - TcSal (mutant) + antibody<br /> | **[[3opz]] - TcSal (mutant) + antibody<br /> | ||
| - | **[[1sli]], [[2sli]], [[3sli]], [[4sli]] - | + | **[[1sll]] – lSal L - leech<br /> |
| + | **[[1sli]], [[2sli]], [[3sli]], [[4sli]] - lSal + neuraminic acid derivative <br /> | ||
**[[4x47]], [[4x4a]] - RgSal + neuraminic acid derivative - ''Ruminococcus gnavus''<br /> | **[[4x47]], [[4x4a]] - RgSal + neuraminic acid derivative - ''Ruminococcus gnavus''<br /> | ||
**[[4x49]] - RgSal + tamiflu<br /> | **[[4x49]] - RgSal + tamiflu<br /> | ||
Revision as of 11:30, 6 November 2018
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3D structures of salidase
Updated on 06-November-2018
References
- ↑ Monti E, Preti A, Venerando B, Borsani G. Recent development in mammalian sialidase molecular biology. Neurochem Res. 2002 Aug;27(7-8):649-63. PMID:12374200
- ↑ Paris G, Ratier L, Amaya MF, Nguyen T, Alzari PM, Frasch AC. A sialidase mutant displaying trans-sialidase activity. J Mol Biol. 2005 Jan 28;345(4):923-34. PMID:15588836 doi:10.1016/j.jmb.2004.09.031
- ↑ Colli W. Trans-sialidase: a unique enzyme activity discovered in the protozoan Trypanosoma cruzi. FASEB J. 1993 Oct;7(13):1257-64. PMID:8405811
- ↑ Miller BR 3rd, Roitberg AE. Trypanosoma cruzi trans-sialidase as a drug target against Chagas disease (American trypanosomiasis). Future Med Chem. 2013 Oct;5(15):1889-900. doi: 10.4155/fmc.13.129. PMID:24144418 doi:http://dx.doi.org/10.4155/fmc.13.129
