Thiamin phosphate synthase

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(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Thiamin phosphate synthase''' (TPS) catalyzes the synthesisd of 4-...)
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<StructureSection load='2tps' size='340' side='right' caption='Caption for this structure' scene=''>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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== Function ==
== Function ==
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'''Thiamin phosphate synthase''' (TPS) catalyzes the synthesisd of 4-methyl-5 (β-hydroxyethyl)thiazole phosphate (thz-P) amd 4-amino-5(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to produce thiamin phosphate and pyrophosphate<ref>PMID:11513588</ref>
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'''Thiamin phosphate synthase''' (TPS) catalyzes the synthesisd of 4-methyl-5 (β-hydroxyethyl)thiazole phosphate (Thz-P) amd 4-amino-5(hydroxymethyl)-2-methylpyrimidine pyrophosphate (HMP-PP) to produce thiamin phosphate and pyrophosphate<ref>PMID:11513588</ref>
== Disease ==
== Disease ==
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</StructureSection>
</StructureSection>
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[[1g4e]], [[3o16]] - BsTPS (mutant) - Bacillus subtilis<br />
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==3D structures of thiamin phosphate synthase==
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[[1g4p]] - BsTPS (mutant) + pyrimidine derivative<br />
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[[1g67]], [[1g69]], [[1g6c]] - BsTPS (mutant) + pyrimidine derivative + PPi<br />
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[1g4e]], [[3o16]] - BsTPS (mutant) - ''Bacillus subtilis''<br />
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[[1g4p]] - BsTPS (mutant) + Thz-P<br />
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[[1g67]], [[1g69]], [[1g6c]] - BsTPS (mutant) + Thz-P + PPi<br />
[[1g4t]] - BsTPS + thiamine phosphate derivative<br />
[[1g4t]] - BsTPS + thiamine phosphate derivative<br />
[[1g4s]] - BsTPS (mutant) + thiamine phosphate derivative<br />
[[1g4s]] - BsTPS (mutant) + thiamine phosphate derivative<br />
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[[2tps]] - BsTPS + thiamine phosphate derivative + PPi<br />
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[[2tps]] - BsTPS + thiamine phosphate + PPi<br />
[[3o15]] - BsTPS + thiazole phosphate derivative + PPi<br />
[[3o15]] - BsTPS + thiazole phosphate derivative + PPi<br />
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[[3o63]] - TPS + Pi - Mycobacterium tuberculosis<br />
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[[3o63]] - TPS + Pi - ''Mycobacterium tuberculosis''<br />
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[[1xi3]] - TPS - Pyrococcus furiosus<br />
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[[1xi3]] - TPS - ''Pyrococcus furiosus''<br />
== References ==
== References ==
<references/>
<references/>
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[[Category:Topic Page]]

Revision as of 07:43, 12 November 2018

Caption for this structure

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3D structures of thiamin phosphate synthase

Updated on 12-November-2018

1g4e, 3o16 - BsTPS (mutant) - Bacillus subtilis
1g4p - BsTPS (mutant) + Thz-P
1g67, 1g69, 1g6c - BsTPS (mutant) + Thz-P + PPi
1g4t - BsTPS + thiamine phosphate derivative
1g4s - BsTPS (mutant) + thiamine phosphate derivative
2tps - BsTPS + thiamine phosphate + PPi
3o15 - BsTPS + thiazole phosphate derivative + PPi
3o63 - TPS + Pi - Mycobacterium tuberculosis
1xi3 - TPS - Pyrococcus furiosus

References

  1. ↑ Reddick JJ, Nicewonger R, Begley TP. Mechanistic studies on thiamin phosphate synthase: evidence for a dissociative mechanism. Biochemistry. 2001 Aug 28;40(34):10095-102. PMID:11513588

Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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