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Myomesin

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(New page: <StructureSection load='2y23' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Myomesin''' or '''Skelemin''' is expressed in striated muscle cell...)
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<StructureSection load='2y23' size='340' side='right' caption='Human myomesin-1 immunoglobulin-like domains 9-11 (PDB code [[2y23]])' scene=''>
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<StructureSection load='2y23' size='340' side='right' caption='Caption for this structure' scene=''>
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== Function ==
== Function ==
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== Structural highlights ==
== Structural highlights ==
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The structure of myomesin-1 domains 9-11 show a superhelical coil arrangement which can be stretched to about 2.5-fold of its original length by reversible unfolding of the linkers. This property of the protein can explains its role in the elasticity of muscle fibers<ref>PMID:22347812</ref>.
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Revision as of 09:58, 12 November 2018

Human myomesin-1 immunoglobulin-like domains 9-11 (PDB code 2y23)

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3D structures of myomesin

Updated on 12-November-2018

5fm4, 5fm8 - hMyo-1 domain 4 510-618 - human
5fm5 - hMyo-1 domains 4-5 510-739 + obscurin-like-1
2y23 - hMyo-1 domains 9-11 1141-1447
2r15 - hMyo-1 domains 12-13 1225-1443
3rbs - hMyo-1 domains 10-11 1247-1447
4v10 - hMyo-1 domains 12-13 1225-1443 (mutant)
2jtd - hMyo-1 1207-1328 - NMR
2y25 - hMyo-1 domains 11-13 1357-1667

References

  1. ↑ Reddy KB, Fox JE, Price MG, Kulkarni S, Gupta S, Das B, Smith DM. Nuclear localization of Myomesin-1: possible functions. J Muscle Res Cell Motil. 2008;29(1):1-8. doi: 10.1007/s10974-008-9137-x. Epub, 2008 Jun 3. PMID:18521710 doi:http://dx.doi.org/10.1007/s10974-008-9137-x
  2. ↑ Schoenauer R, Bertoncini P, Machaidze G, Aebi U, Perriard JC, Hegner M, Agarkova I. Myomesin is a molecular spring with adaptable elasticity. J Mol Biol. 2005 Jun 3;349(2):367-79. doi: 10.1016/j.jmb.2005.03.055. Epub 2005, Apr 7. PMID:15890201 doi:http://dx.doi.org/10.1016/j.jmb.2005.03.055
  3. ↑ Pinotsis N, Chatziefthimiou SD, Berkemeier F, Beuron F, Mavridis IM, Konarev PV, Svergun DI, Morris E, Rief M, Wilmanns M. Superhelical architecture of the Myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol. 2012 Feb;10(2):e1001261. Epub 2012 Feb 14. PMID:22347812 doi:10.1371/journal.pbio.1001261

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Michal Harel

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