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Myomesin

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== Function ==
== Function ==
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'''Myomesin''' or '''Skelemin''' is expressed in striated muscle cells. It contains type-III fibronectin (motif I) and C2-immunoglobulin (motif II) domains<ref>PMID:18521710</ref>. Myomesin is found in the M-bridges of sarcomeres which produce the muscle contraction and provide their elasticity. The giant protein [[Titin]] interconnects the major structure of sarcomeres - the M bands and Z discs. The C-terminal of titin binds to myomesin-1 and myomesin-2. Myomesin-1 and myomesin-2 have a unique N-terminal region followed by 12 motifs in the order of II-II-I-I-I-I-I-II-II-II-II-II<ref>PMID:15890201</ref>.
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'''Myomesin''' or '''Skelemin''' is expressed in striated muscle cells. It contains type-III fibronectin (motif I) and C2-immunoglobulin (motif II) domains<ref>PMID:18521710</ref>. Myomesin is found in the M-bridges of sarcomeres which produce the muscle contraction and provide their elasticity. The giant protein [[Titin]] interconnects the major structure of sarcomeres - the M bands and Z discs. The C-terminal of titin binds to myomesin-1 and myomesin-2. Myomesin-1 and myomesin-2 have a unique N-terminal region followed by 12 motifs in the order of<br /> II-II-I-I-I-I-I-II-II-II-II-II<ref>PMID:15890201</ref>.
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== Disease ==
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== Relevance ==
== Relevance ==
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The up-regulation of myimesin denotes an adaptive remodeling of the sarcomere cytoskeleton in dilated heart and mya serve as a marker for dilated cardiomyopathy<ref>PMID:21069531</ref>.
== Structural highlights ==
== Structural highlights ==

Revision as of 10:05, 12 November 2018

Human myomesin-1 immunoglobulin-like domains 9-11 (PDB code 2y23)

Drag the structure with the mouse to rotate

3D structures of myomesin

Updated on 12-November-2018

5fm4, 5fm8 - hMyo-1 domain 4 510-618 - human
5fm5 - hMyo-1 domains 4-5 510-739 + obscurin-like-1
2y23 - hMyo-1 domains 9-11 1141-1447
2r15 - hMyo-1 domains 12-13 1225-1443
3rbs - hMyo-1 domains 10-11 1247-1447
4v10 - hMyo-1 domains 12-13 1225-1443 (mutant)
2jtd - hMyo-1 1207-1328 - NMR
2y25 - hMyo-1 domains 11-13 1357-1667

References

  1. ↑ Reddy KB, Fox JE, Price MG, Kulkarni S, Gupta S, Das B, Smith DM. Nuclear localization of Myomesin-1: possible functions. J Muscle Res Cell Motil. 2008;29(1):1-8. doi: 10.1007/s10974-008-9137-x. Epub, 2008 Jun 3. PMID:18521710 doi:http://dx.doi.org/10.1007/s10974-008-9137-x
  2. ↑ Schoenauer R, Bertoncini P, Machaidze G, Aebi U, Perriard JC, Hegner M, Agarkova I. Myomesin is a molecular spring with adaptable elasticity. J Mol Biol. 2005 Jun 3;349(2):367-79. doi: 10.1016/j.jmb.2005.03.055. Epub 2005, Apr 7. PMID:15890201 doi:http://dx.doi.org/10.1016/j.jmb.2005.03.055
  3. ↑ Schoenauer R, Emmert MY, Felley A, Ehler E, Brokopp C, Weber B, Nemir M, Faggian GG, Pedrazzini T, Falk V, Hoerstrup SP, Agarkova I. EH-myomesin splice isoform is a novel marker for dilated cardiomyopathy. Basic Res Cardiol. 2011 Mar;106(2):233-47. doi: 10.1007/s00395-010-0131-2. Epub, 2010 Nov 11. PMID:21069531 doi:http://dx.doi.org/10.1007/s00395-010-0131-2
  4. ↑ Pinotsis N, Chatziefthimiou SD, Berkemeier F, Beuron F, Mavridis IM, Konarev PV, Svergun DI, Morris E, Rief M, Wilmanns M. Superhelical architecture of the Myosin filament-linking protein myomesin with unusual elastic properties. PLoS Biol. 2012 Feb;10(2):e1001261. Epub 2012 Feb 14. PMID:22347812 doi:10.1371/journal.pbio.1001261

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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