Colony-stimulating factor receptor
From Proteopedia
(Difference between revisions)
(New page: <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Colony-stimulating factor receptor''' (CSFR) are binding the [[Col...) |
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
== Function == | == Function == | ||
| - | '''Colony-stimulating factor receptor''' (CSFR) are binding the [[Colony-stimulating factor]]s and thus mediating the lineage-specific growth of cells of the mononuclear phagocytes series as bone marrow-derived precursors of monocytes and macrophages<ref>PMID:2852667</ref>. | + | '''Colony-stimulating factor receptor''' (CSFR) are binding the [[Colony-stimulating factor]]s and thus mediating the lineage-specific growth of cells of the mononuclear phagocytes series as bone marrow-derived precursors of monocytes and macrophages<ref>PMID:2852667</ref>. The '''granulocyte colony stimulating factor receptor''' (G-CSFR) participates in the development, survival and activation of neutrophilic granulocytes and in the development of other myeloid lineages. |
== Disease == | == Disease == | ||
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| + | Mutations in G-CSFR were found in patients with severe congenital neutropenia<ref>PMID:9001427</ref>. | ||
== Relevance == | == Relevance == | ||
Revision as of 10:37, 15 November 2018
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3D structures of colony-stimulating factor receptor
Updated on 15-November-2018
References
- ↑ Sherr CJ, Roussel MF, Rettenmier CW. Colony-stimulating factor-1 receptor (c-fms). J Cell Biochem. 1988 Nov;38(3):179-87. doi: 10.1002/jcb.240380305. PMID:2852667 doi:http://dx.doi.org/10.1002/jcb.240380305
- ↑ Dong F, Dale DC, Bonilla MA, Freedman M, Fasth A, Neijens HJ, Palmblad J, Briars GL, Carlsson G, Veerman AJ, Welte K, Lowenberg B, Touw IP. Mutations in the granulocyte colony-stimulating factor receptor gene in patients with severe congenital neutropenia. Leukemia. 1997 Jan;11(1):120-5. PMID:9001427
