Galactoside O-acetyltransferase
From Proteopedia
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(New page: <StructureSection load='1krr' size='340' side='right' caption='Caption for this structure' scene=''> == Function == '''Galactoside O-acetyltransferase''' (GAT) assists cellular detoxifi...) |
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| - | + | <StructureSection load='1krr' size='340' side='right' caption='Galactoside O-acetyltransferase complex with acetyl-CoA (PDB code [[1krr]])' scene=''> | |
| - | <StructureSection load='1krr' size='340' side='right' caption=' | + | |
== Function == | == Function == | ||
| - | '''Galactoside O-acetyltransferase''' (GAT) assists cellular detoxification by acetylating the 6-hydroxyl group of nonmetabolizable pyranosides like galactosides, glucosides and lactosides and thus preventing their reentry into the cell<ref>PMID:11937062</ref>. GAT gene is part of the ''lac'' operon<ref>PMID:15950163</ref>. | + | '''Galactoside O-acetyltransferase''' (GAT) assists cellular detoxification by acetylating the 6-hydroxyl group of nonmetabolizable pyranosides like galactosides, glucosides and lactosides and thus preventing their reentry into the cell<ref name="GAT">PMID:11937062</ref>. GAT gene is part of the ''lac'' operon<ref>PMID:15950163</ref>. |
== Structural highlights == | == Structural highlights == | ||
| + | The structure of the complex of GAT with the cofactor acetyl-CoA shows that the latter binds to residues in a crevice between two subunits<ref name="GAT"/>. | ||
</StructureSection> | </StructureSection> | ||
Revision as of 10:49, 20 November 2018
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3D structures of galactoside O-acetyltransferase
Updated on 20-November-2018
1kqa, 1krr – EcGAT + Acetyl CoA – Escherichia coli
1kru, 1krv – EcGAT + Acetyl CoA + galactopyranose derivative
3ftt – SaGAT – Staphylococcus aureus
3v4e, 5u2k, 5v0z – SaGAT + Acetyl CoA
3vbi – BcGAT + Acetyl CoA + TDP derivative – Bacillus cereus
3vbn, 3vbp, 3vbk, 3vbl, 3vbm – BcGAT (mutant) + Acetyl CoA + TDP derivative
3vbj – BcGAT + butyryl CoA + TDP
References
- ↑ 1.0 1.1 Wang XG, Olsen LR, Roderick SL. Structure of the lac operon galactoside acetyltransferase. Structure. 2002 Apr;10(4):581-8. PMID:11937062
- ↑ Roderick SL. The lac operon galactoside acetyltransferase. C R Biol. 2005 Jun;328(6):568-75. doi: 10.1016/j.crvi.2005.03.005. PMID:15950163 doi:http://dx.doi.org/10.1016/j.crvi.2005.03.005
