Syntaxin

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	*Syntaxin 17		*Syntaxin 17
-	**[[4wy4]] – rStx17 SNARE motif + SNAP25 + VAMP8<br />	+	**[[4wy4]] – rStx17 SNARE motif + SNAP29 + VAMP8<br />
	*s-syntaxin		*s-syntaxin

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Revision as of 10:48, 29 November 2018

spinqualitylabelsall models Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (grey) and SNAP25 SNARE motif (pink and yellow) (PDB code 3ipd) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Function Syntaxin (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles. Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane[1]. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs[2]. Relevance The blockade of Stx-1 inhibits glioblastoma tumor growth and may represent a novel therapeutic tool against this fatal tumor[3]. Structural highlights The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions[4].

3D structures of syntaxin

Updated on 29-November-2018

References

1. ↑ Hussain S, Ringsevjen H, Egbenya DL, Skjervold TL, Davanger S. SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus. Front Mol Neurosci. 2016 Feb 5;9:10. doi: 10.3389/fnmol.2016.00010. eCollection, 2016. PMID:26903802 doi:http://dx.doi.org/10.3389/fnmol.2016.00010
2. ↑ Liang B, Kiessling V, Tamm LK. Prefusion structure of syntaxin-1A suggests pathway for folding into neuronal trans-SNARE complex fusion intermediate. Proc Natl Acad Sci U S A. 2013 Nov 11. PMID:24218570 doi:http://dx.doi.org/10.1073/pnas.1314699110
3. ↑ Hussain S, Ringsevjen H, Egbenya DL, Skjervold TL, Davanger S. SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus. Front Mol Neurosci. 2016 Feb 5;9:10. doi: 10.3389/fnmol.2016.00010. eCollection, 2016. PMID:26903802 doi:http://dx.doi.org/10.3389/fnmol.2016.00010
4. ↑ Stein A, Weber G, Wahl MC, Jahn R. Helical extension of the neuronal SNARE complex into the membrane. Nature. 2009 Jul 23;460(7254):525-8. Epub 2009 Jul 1. PMID:19571812 doi:10.1038/nature08156