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5zvb

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'''Unreleased structure'''
 
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The entry 5zvb is ON HOLD
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==APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dT9)==
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<StructureSection load='5zvb' size='340' side='right' caption='[[5zvb]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Cheng, C., Zhang, T.L., Wang, C.X., Lan, W.X., Ding, J.P., Cao, C.Y.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5zvb]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ZVB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ZVB FirstGlance]. <br>
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Description: Crystal structure of APOBEC3F catalytic domain in complex with DNA
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CAC:CACODYLATE+ION'>CAC</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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[[Category: Ding, J.P]]
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">APOBEC3F ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5zvb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5zvb OCA], [http://pdbe.org/5zvb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5zvb RCSB], [http://www.ebi.ac.uk/pdbsum/5zvb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5zvb ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/ABC3G_HUMAN ABC3G_HUMAN]] DNA deaminase (cytidine deaminase) that mediates a form of innate resistance to retroviral infections (at least to HIV-1 infection) by triggering G-to-A hypermutation in the newly synthesized viral DNA. The replacements C-to-U in the minus strand DNA of HIV-1 during reverse transcription, leads to G-to-A transitions in the plus strand. The inhibition of viral replication is either due to the degradation of the minus strand before its integration or to the lethality of the hypermutations. Modification of both DNA strands is not excluded. This antiviral activity is neutralized by the virion infectivity factor (VIF), that prevents the incorporation of APOBEC3G into progeny HIV-1 virions by both inhibiting its translation and/or by inducing its ubiquitination and subsequent degradation by the 26S proteasome. May also prevent the transposition of a subset of retroelements. Binds a variety of RNAs, but does not display detectable APOB, NF1 and NAT1 mRNA editing.<ref>PMID:14557625</ref> <ref>PMID:12167863</ref> <ref>PMID:12808466</ref> <ref>PMID:12809610</ref> <ref>PMID:12808465</ref> <ref>PMID:12859895</ref> <ref>PMID:12970355</ref> <ref>PMID:14528300</ref> <ref>PMID:15031497</ref> <ref>PMID:16527742</ref> <ref>PMID:21123384</ref> <ref>PMID:18288108</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Human]]
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[[Category: Cao, C Y]]
[[Category: Cheng, C]]
[[Category: Cheng, C]]
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[[Category: Lan, W.X]]
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[[Category: Ding, J P]]
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[[Category: Wang, C.X]]
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[[Category: Lan, W X]]
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[[Category: Cao, C.Y]]
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[[Category: Wang, C X]]
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[[Category: Zhang, T.L]]
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[[Category: Zhang, T L]]
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[[Category: Apobec3f]]
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[[Category: Deamination]]
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[[Category: Hiv-1]]
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[[Category: Structural protein-dna complex]]

Current revision

APOBEC3F Chimeric Catalytic Domain in Complex with DNA(dT9)

5zvb, resolution 2.00Å

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