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| - | | + | #REDIRECT [[6n1i]] This PDB entry is obsolete and replaced by 6n1i |
| - | ==Cryo-EM Structures of ASC and NLRC4 CARD Filaments Reveal a Unified Mechanism of Nucleation and Activation of Caspase-1==
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| - | <StructureSection load='6drp' size='340' side='right' caption='[[6drp]], [[Resolution|resolution]] 3.58Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[6drp]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6DRP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6DRP FirstGlance]. <br>
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| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6drp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6drp OCA], [http://pdbe.org/6drp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6drp RCSB], [http://www.ebi.ac.uk/pdbsum/6drp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6drp ProSAT]</span></td></tr>
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| - | </table>
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| - | == Disease ==
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| - | [[http://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN]] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN]] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).[UniProtKB:Q3UP24]<ref>PMID:15107016</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Fu, T]]
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| - | [[Category: Li, Y]]
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| - | [[Category: Wu, H]]
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| - | [[Category: Complex]]
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| - | [[Category: Filament]]
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| - | [[Category: Immune system]]
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| - | [[Category: Innate immunity]]
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| - | [[Category: Signaling]]
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Current revision
- REDIRECT 6n1i This PDB entry is obsolete and replaced by 6n1i
