5jt8
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='5jt8' size='340' side='right' caption='[[5jt8]], [[Resolution|resolution]] 2.10Å' scene=''> | <StructureSection load='5jt8' size='340' side='right' caption='[[5jt8]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5jt8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JT8 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5jt8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Blota Blota]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JT8 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jt8 OCA], [http://pdbe.org/5jt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jt8 RCSB], [http://www.ebi.ac.uk/pdbsum/5jt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jt8 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5jt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5jt8 OCA], [http://pdbe.org/5jt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5jt8 RCSB], [http://www.ebi.ac.uk/pdbsum/5jt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5jt8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The Blomia tropicalis (Blo t) mite species is considered a storage mite in temperate climate zones and an important source of indoor allergens causing allergic asthma and rhinitis in tropical and subtropical regions. Here, we report the crystal structure of one of the allergens from Blo t, recombinant proBlo t 1 (rproBlo t 1), determined at 2.1 A resolution. Overall, the fold of rproBlo t 1 is characteristic for the pro-form of cysteine proteases from the C1A class. Structural comparison of experimentally mapped Der f 1/Der p1 IgG epitopes to the same surface patch on Blo t 1, as well as of sequence identity of surface-exposed residues, suggests limited cross-reactivity between these allergens and Blo t 1. This is in agreement with ELISA inhibition results showing that, although cross-reactive human IgE epitopes exist, there are unique IgE epitopes for both Blo t 1 and Der p 1. | ||
| + | |||
| + | The structure of the mite allergen Blo t 1 explains the limited antibody cross-reactivity to Der p 1.,Meno KH, Kastrup JS, Kuo IC, Chua KY, Gajhede M Allergy. 2017 Apr;72(4):665-670. doi: 10.1111/all.13111. Epub 2017 Jan 19. PMID:27997997<ref>PMID:27997997</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 5jt8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Blota]] | ||
[[Category: Gajhede, M]] | [[Category: Gajhede, M]] | ||
[[Category: Kastrup, J S]] | [[Category: Kastrup, J S]] | ||
Revision as of 06:57, 5 December 2018
Structural basis for the limited antibody cross reactivity between the mite allergens Blo t 1 and Der p 1
| |||||||||||
Categories: Blota | Gajhede, M | Kastrup, J S | Meno, K | Allergen | Allergen mite
