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3b2v

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|PDB= 3b2v |SIZE=350|CAPTION= <scene name='initialview01'>3b2v</scene>, resolution 3.30&Aring;
|PDB= 3b2v |SIZE=350|CAPTION= <scene name='initialview01'>3b2v</scene>, resolution 3.30&Aring;
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+3281'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+3282'>AC2</scene>, <scene name='pdbsite=AC3:Ndg+Binding+Site+For+Residue+A+3371'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+A+3891'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+4201'>AC5</scene> and <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+A+5041'>AC6</scene>
|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+3281'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+A+3282'>AC2</scene>, <scene name='pdbsite=AC3:Ndg+Binding+Site+For+Residue+A+3371'>AC3</scene>, <scene name='pdbsite=AC4:Nag+Binding+Site+For+Residue+A+3891'>AC4</scene>, <scene name='pdbsite=AC5:Nag+Binding+Site+For+Residue+A+4201'>AC5</scene> and <scene name='pdbsite=AC6:Nag+Binding+Site+For+Residue+A+5041'>AC6</scene>
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1]
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span>
|GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EGFR, ERBB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
|GENE= EGFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), EGFR, ERBB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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|RELATEDENTRY=[[3b2u|3B2U]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3b2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b2v OCA], [http://www.ebi.ac.uk/pdbsum/3b2v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3b2v RCSB]</span>
}}
}}
'''Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8'''
'''Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8'''
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==Disease==
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Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]], Nonsmall cell lung cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=131550 131550]]
==About this Structure==
==About this Structure==
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[[Category: Kussie, P.]]
[[Category: Kussie, P.]]
[[Category: Li, S.]]
[[Category: Li, S.]]
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[[Category: NAG]]
 
[[Category: alternative splicing]]
[[Category: alternative splicing]]
[[Category: anti-oncogene]]
[[Category: anti-oncogene]]
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[[Category: antigen:antibody complex]]
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[[Category: antitumor]]
[[Category: atp-binding]]
[[Category: atp-binding]]
[[Category: cell cycle]]
[[Category: cell cycle]]
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[[Category: cell surface receptor; glycoprotein; antigen:antibody complex; fab fragment; antitumor; drug]]
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[[Category: cell surface receptor]]
[[Category: disease mutation]]
[[Category: disease mutation]]
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[[Category: drug]]
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[[Category: fab fragment]]
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[[Category: glycoprotein]]
[[Category: immune system/transferase complex]]
[[Category: immune system/transferase complex]]
[[Category: kinase]]
[[Category: kinase]]
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[[Category: ubl conjugation]]
[[Category: ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:55:37 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 05:22:31 2008''

Revision as of 02:22, 31 March 2008

Image:3b2v.jpg


PDB ID 3b2v

Drag the structure with the mouse to rotate
, resolution 3.30Å
Sites: , , , , and
Ligands: , ,
Gene: EGFR (Homo sapiens), EGFR, ERBB1 (Homo sapiens)
Activity: Receptor protein-tyrosine kinase, with EC number 2.7.10.1
Related: 3B2U


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal structure of the extracellular region of the epidermal growth factor receptor in complex with the Fab fragment of IMC-11F8


Disease

Known disease associated with this structure: Adenocarcinoma of lung, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in OMIM:[131550], Nonsmall cell lung cancer, susceptibility to OMIM:[131550]

About this Structure

3B2V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Page seeded by OCA on Mon Mar 31 05:22:31 2008

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