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3ixj

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==Crystal structure of beta-secretase 1 in complex with selective beta-secretase 1 inhibitor==
==Crystal structure of beta-secretase 1 in complex with selective beta-secretase 1 inhibitor==
<StructureSection load='3ixj' size='340' side='right' caption='[[3ixj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3ixj' size='340' side='right' caption='[[3ixj]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BACE, BACE1, KIAA1149 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Memapsin_2 Memapsin 2], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.46 3.4.23.46] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixj OCA], [http://pdbe.org/3ixj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixj RCSB], [http://www.ebi.ac.uk/pdbsum/3ixj PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ixj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ixj OCA], [http://pdbe.org/3ixj PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3ixj RCSB], [http://www.ebi.ac.uk/pdbsum/3ixj PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3ixj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ixj_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ix/3ixj_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Lindberg, J]]
[[Category: Lindberg, J]]
[[Category: Nystrom, S]]
[[Category: Nystrom, S]]
 +
[[Category: Alternative splicing]]
[[Category: Aspartyl protease]]
[[Category: Aspartyl protease]]
[[Category: Bace]]
[[Category: Bace]]
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[[Category: Inhibitor]]
[[Category: Inhibitor]]
[[Category: Membrane]]
[[Category: Membrane]]
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[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Protease]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
[[Category: Zymogen]]
[[Category: Zymogen]]

Revision as of 09:19, 19 December 2018

Crystal structure of beta-secretase 1 in complex with selective beta-secretase 1 inhibitor

3ixj, resolution 2.20Å

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