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3jyh
From Proteopedia
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==Human dipeptidyl peptidase DPP7== | ==Human dipeptidyl peptidase DPP7== | ||
<StructureSection load='3jyh' size='340' side='right' caption='[[3jyh]], [[Resolution|resolution]] 2.19Å' scene=''> | <StructureSection load='3jyh' size='340' side='right' caption='[[3jyh]], [[Resolution|resolution]] 2.19Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3jyh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3jyh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JYH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3JYH FirstGlance]. <br> |
| - | </td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>< | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | <tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DPP2, DPP7, QPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DPP2, DPP7, QPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_II Dipeptidyl-peptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.2 3.4.14.2] </span></td></tr> | + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_II Dipeptidyl-peptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.2 3.4.14.2] </span></td></tr> |
| - | <tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jyh OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3jyh RCSB], [http://www.ebi.ac.uk/pdbsum/3jyh PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3jyh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jyh OCA], [http://pdbe.org/3jyh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3jyh RCSB], [http://www.ebi.ac.uk/pdbsum/3jyh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3jyh ProSAT]</span></td></tr> |
| - | <table> | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DPP2_HUMAN DPP2_HUMAN]] Plays an important role in the degradation of some oligopeptides.<ref>PMID:15487984</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/3jyh_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/jy/3jyh_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jyh ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
*[[Dipeptidyl peptidase|Dipeptidyl peptidase]] | *[[Dipeptidyl peptidase|Dipeptidyl peptidase]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Dipeptidyl-peptidase II]] | [[Category: Dipeptidyl-peptidase II]] | ||
| - | [[Category: | + | [[Category: Human]] |
| - | [[Category: Arrowsmith, C H | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Bochkarev, A | + | [[Category: Bochkarev, A]] |
| - | [[Category: Bountra, C | + | [[Category: Bountra, C]] |
| - | [[Category: Cossar, D | + | [[Category: Cossar, D]] |
| - | [[Category: Crombett, L | + | [[Category: Crombett, L]] |
| - | [[Category: Dobrovetsky, E | + | [[Category: Dobrovetsky, E]] |
| - | [[Category: Dong, A | + | [[Category: Dong, A]] |
| - | [[Category: Edwards, A M | + | [[Category: Edwards, A M]] |
| - | [[Category: Hassel, A | + | [[Category: Hassel, A]] |
| - | [[Category: Paganon, S | + | [[Category: Paganon, S]] |
| - | [[Category: | + | [[Category: Structural genomic]] |
| - | [[Category: Seitova, A | + | [[Category: Seitova, A]] |
| - | [[Category: Shewchuk, L | + | [[Category: Shewchuk, L]] |
| - | [[Category: Weigelt, J | + | [[Category: Weigelt, J]] |
[[Category: Aminopeptidase]] | [[Category: Aminopeptidase]] | ||
[[Category: Cleavage on pair of basic residue]] | [[Category: Cleavage on pair of basic residue]] | ||
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[[Category: Serine protease]] | [[Category: Serine protease]] | ||
[[Category: Sgc]] | [[Category: Sgc]] | ||
| - | [[Category: Structural genomic]] | ||
| - | [[Category: Structural genomics consortium]] | ||
[[Category: Zymogen]] | [[Category: Zymogen]] | ||
Current revision
Human dipeptidyl peptidase DPP7
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Categories: Dipeptidyl-peptidase II | Human | Arrowsmith, C H | Bochkarev, A | Bountra, C | Cossar, D | Crombett, L | Dobrovetsky, E | Dong, A | Edwards, A M | Hassel, A | Paganon, S | Structural genomic | Seitova, A | Shewchuk, L | Weigelt, J | Aminopeptidase | Cleavage on pair of basic residue | Cytoplasmic vesicle | Glycoprotein | Hydrolase | Lysosome | Protease | Serine protease | Sgc | Zymogen
