6huo

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'''Unreleased structure'''
 
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The entry 6huo is ON HOLD until Paper Publication
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==CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38.==
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<StructureSection load='6huo' size='340' side='right' caption='[[6huo]], [[Resolution|resolution]] 3.26&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6huo]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HUO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HUO FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=08H:8-CHLORO-1-METHYL-6-PHENYL-4H-[1,2,4]TRIAZOLO[4,3-A][1,4]BENZODIAZEPINE'>08H</scene>, <scene name='pdbligand=ABU:GAMMA-AMINO-BUTANOIC+ACID'>ABU</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PIO:[(2R)-2-OCTANOYLOXY-3-[OXIDANYL-[(1R,2R,3S,4R,5R,6S)-2,3,6-TRIS(OXIDANYL)-4,5-DIPHOSPHONOOXY-CYCLOHEXYL]OXY-PHOSPHORYL]OXY-PROPYL]+OCTANOATE'>PIO</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6huo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6huo OCA], [http://pdbe.org/6huo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6huo RCSB], [http://www.ebi.ac.uk/pdbsum/6huo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6huo ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/GBRG2_HUMAN GBRG2_HUMAN]] Childhood absence epilepsy;Dravet syndrome;Generalized epilepsy with febrile seizures-plus. Disease susceptibility is associated with variations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. [[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] Autism;Childhood absence epilepsy. Disease susceptibility is associated with variations affecting the gene represented in this entry.
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== Function ==
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[[http://www.uniprot.org/uniprot/GBRA1_BOVIN GBRA1_BOVIN]] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.<ref>PMID:3037384</ref> [[http://www.uniprot.org/uniprot/GBRG2_HUMAN GBRG2_HUMAN]] Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel.<ref>PMID:2538761</ref> [[http://www.uniprot.org/uniprot/GBRB3_HUMAN GBRB3_HUMAN]] GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Aricescu, A R]]
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[[Category: Desai, R]]
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[[Category: Jasenko, Z]]
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[[Category: Karia, D]]
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[[Category: Kotecha, A]]
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[[Category: Laverty, D]]
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[[Category: Malinauskas, T]]
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[[Category: Martin, I Serna]]
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[[Category: Masiulis, S]]
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[[Category: Miller, K W]]
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[[Category: Pardon, E]]
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[[Category: Steyaert, J]]
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[[Category: Uchanski, T]]
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[[Category: Cys-loop receptor]]
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[[Category: Gabaar]]
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[[Category: Membrane protein]]
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[[Category: Plgic]]

Revision as of 06:11, 2 January 2019

CryoEM structure of human full-length heteromeric alpha1beta3gamma2L GABA(A)R in complex with alprazolam (Xanax), GABA and megabody Mb38.

6huo, resolution 3.26Å

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