A-kinase anchor protein

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An <scene name='77/777613/Cv/5'>ampiphatic helix of AKAP18 binds with its hydrophobic sides to helices of the PKA regulatory subunit</scene><ref>PMID:27102985</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}
An <scene name='77/777613/Cv/5'>ampiphatic helix of AKAP18 binds with its hydrophobic sides to helices of the PKA regulatory subunit</scene><ref>PMID:27102985</ref>. {{Template:ColorKey_Hydrophobic}}, {{Template:ColorKey_Polar}}
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*<scene name='77/777613/Cv/6'>1st Cd coordination site</scene>.
 
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*<scene name='77/777613/Cv/7'>2nd Cd coordination site</scene>.
 
</StructureSection>
</StructureSection>

Revision as of 08:50, 3 January 2019

Human AKAP18 helix (deepskyblue) complex with a dimer of cAMP-dependent protein kinase regulatory subunit (magenta and green) and Cd+2 ions (PDB code 4zp3)

Drag the structure with the mouse to rotate

3D Structures of A-kinase anchor protein

Updated on 03-January-2019

References

  1. ↑ Edwards AS, Scott JD. A-kinase anchoring proteins: protein kinase A and beyond. Curr Opin Cell Biol. 2000 Apr;12(2):217-21. PMID:10712918
  2. ↑ Carr DW, Newell AE. The role of A-kinase anchoring proteins (AKaps) in regulating sperm function. Soc Reprod Fertil Suppl. 2007;63:135-41. PMID:17566268
  3. ↑ Diviani D, Dodge-Kafka KL, Li J, Kapiloff MS. A-kinase anchoring proteins: scaffolding proteins in the heart. Am J Physiol Heart Circ Physiol. 2011 Nov;301(5):H1742-53. doi:, 10.1152/ajpheart.00569.2011. Epub 2011 Aug 19. PMID:21856912 doi:http://dx.doi.org/10.1152/ajpheart.00569.2011
  4. ↑ Gotz F, Roske Y, Schulz MS, Autenrieth K, Bertinetti D, Faelber K, Zuhlke K, Kreuchwig A, Kennedy E, Krause G, Daumke O, Herberg FW, Heinemann U, Klussmann E. AKAP18:PKA-RIIalpha structure reveals crucial anchor points for recognition of regulatory subunits of PKA. Biochem J. 2016 Apr 21. pii: BCJ20160242. PMID:27102985 doi:http://dx.doi.org/10.1042/BCJ20160242

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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