This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3mj7

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (07:50, 9 January 2019) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3mj7.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR==
-
The line below this paragraph, containing "STRUCTURE_3mj7", creates the "Structure Box" on the page.
+
<StructureSection load='3mj7' size='340' side='right' caption='[[3mj7]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3mj7]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MJ7 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-
-->
+
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mj6|3mj6]], [[3mj8|3mj8]], [[3mj9|3mj9]]</td></tr>
-
{{STRUCTURE_3mj7| PDB=3mj7 | SCENE= }}
+
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Amica1, Gm638, Jaml ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Car, Cxadr ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mj7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mj7 OCA], [http://pdbe.org/3mj7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mj7 RCSB], [http://www.ebi.ac.uk/pdbsum/3mj7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mj7 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[[http://www.uniprot.org/uniprot/JAML1_MOUSE JAML1_MOUSE]] Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, AMICA1 induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.<ref>PMID:20813954</ref> [[http://www.uniprot.org/uniprot/CXAR_MOUSE CXAR_MOUSE]] Component of the epithelial apical junction complex that is essential for the tight junction integrity. Proposed to function as a homophilic cell adhesion molecule. Recruits MPDZ to intercellular contact sites. Probably involved in transepithelial migration of polymorphonuclear leukocytes (PMN) through adhesive interactions with AMICA1/JAML located in the plasma membrane of PMN (By similarity).<ref>PMID:9036860</ref> <ref>PMID:9420240</ref> <ref>PMID:10814828</ref> In vitro, acts as a receptor for group B coxsackieviruses and subgroup C of adenoviruses (AD2 and AD5).<ref>PMID:9036860</ref> <ref>PMID:9420240</ref> <ref>PMID:10814828</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mj/3mj7_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mj7 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Coxsackie and adenovirus receptor (CAR) is the primary cellular receptor for group B coxsackieviruses and most adenovirus serotypes and plays a crucial role in adenoviral gene therapy. Recent discovery of the interaction between junctional adhesion molecule-like protein (JAML) and CAR uncovered important functional roles in immunity, inflammation, and tissue homeostasis. Crystal structures of JAML ectodomain (2.2 angstroms) and its complex with CAR (2.8 angstroms) reveal an unusual immunoglobulin-domain assembly for JAML and a charged interface that confers high specificity. Biochemical and mutagenesis studies illustrate how CAR-mediated clustering of JAML recruits phosphoinositide 3-kinase (P13K) to a JAML intracellular sequence motif as delineated for the alphabeta T cell costimulatory receptor CD28. Thus, CAR and JAML are cell signaling receptors of the immune system with implications for asthma, cancer, and chronic nonhealing wounds.
-
===Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR===
+
The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K.,Verdino P, Witherden DA, Havran WL, Wilson IA Science. 2010 Sep 3;329(5996):1210-4. PMID:20813955<ref>PMID:20813955</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
<!--
+
</div>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20813955}}, adds the Publication Abstract to the page
+
<div class="pdbe-citations 3mj7" style="background-color:#fffaf0;"></div>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20813955 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_20813955}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Lk3 transgenic mice]]
-
3MJ7 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MJ7 OCA].
+
[[Category: Verdino, P]]
-
 
+
[[Category: Wilson, I A]]
-
==Reference==
+
-
<ref group="xtra">PMID:20813955</ref><ref group="xtra">PMID:20813954</ref><references group="xtra"/>
+
-
[[Category: Mus musculus]]
+
-
[[Category: Verdino, P.]]
+
-
[[Category: Wilson, I A.]]
+
[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Cell junction]]
[[Category: Cell junction]]
Line 41: Line 51:
[[Category: Tight junction]]
[[Category: Tight junction]]
[[Category: Transmembrane]]
[[Category: Transmembrane]]
- 
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 22 14:46:36 2010''
 

Current revision

Crystal structure of the complex of JAML and Coxsackie and Adenovirus receptor, CAR

3mj7, resolution 2.80Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3mj7"
Personal tools