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6f83
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6f83 is ON HOLD Authors: Collins, P.M., Blanchard, H. Description: Crystal Structure of Human Galectin-1 in Complex With Thienyl-1,2, 3-triazolyl T...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Human Galectin-1 in Complex With Thienyl-1,2, 3-triazolyl Thiodigalactoside Inhibitor== | |
| - | + | <StructureSection load='6f83' size='340' side='right' caption='[[6f83]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6f83]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6F83 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6F83 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5KT:3-DEOXY-3-[4-(THIOPHEN-3-YL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSYL+3-DEOXY-1-THIO-3-[4-(THIOPHEN-3-YL)-1H-1,2,3-TRIAZOL-1-YL]-BETA-D-GALACTOPYRANOSIDE'>5KT</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6f83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6f83 OCA], [http://pdbe.org/6f83 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6f83 RCSB], [http://www.ebi.ac.uk/pdbsum/6f83 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6f83 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Blanchard, H]] | [[Category: Blanchard, H]] | ||
| - | [[Category: Collins, P | + | [[Category: Collins, P M]] |
| + | [[Category: Beta sandwich]] | ||
| + | [[Category: Carbohydrate binding protein]] | ||
| + | [[Category: Carbohydrate-recognition]] | ||
| + | [[Category: Sugar binding protein]] | ||
Current revision
Crystal Structure of Human Galectin-1 in Complex With Thienyl-1,2, 3-triazolyl Thiodigalactoside Inhibitor
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