6nlc

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m (Protected "6nlc" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 6nlc is ON HOLD
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==Crystal structure of HMCES SRAP domain in complex with 6-nucleotide 3' overhang DNA==
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<StructureSection load='6nlc' size='340' side='right' caption='[[6nlc]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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Authors: Halabelian, L., Li, Y., Ravichandran, M., Zheng, H., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6nlc]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6NLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6NLC FirstGlance]. <br>
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Description: Crystal structure of HMCES SRAP domain in complex with 3' overhang DNA
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6nlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6nlc OCA], [http://pdbe.org/6nlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6nlc RCSB], [http://www.ebi.ac.uk/pdbsum/6nlc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6nlc ProSAT]</span></td></tr>
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[[Category: Zheng, H]]
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</table>
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[[Category: Edwards, A.M]]
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== Function ==
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[[Category: Arrowsmith, C.H]]
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[[http://www.uniprot.org/uniprot/HMCES_HUMAN HMCES_HUMAN]] Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (PubMed:23945014).<ref>PMID:23945014</ref>
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[[Category: Structural Genomics Consortium (Sgc)]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra, C]]
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[[Category: Edwards, A M]]
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[[Category: Halabelian, L]]
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[[Category: Li, Y]]
[[Category: Ravichandran, M]]
[[Category: Ravichandran, M]]
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[[Category: Li, Y]]
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[[Category: Structural genomic]]
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[[Category: Halabelian, L]]
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[[Category: Zeng, H]]
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[[Category: Bountra, C]]
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[[Category: 3' overhang]]
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[[Category: Dna binding protein-dna complex]]
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[[Category: Dna damage protein]]
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[[Category: Dna-binding]]
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[[Category: Hmce]]
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[[Category: Protein-dna complex]]
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[[Category: Sgc]]
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[[Category: Srap domain]]

Revision as of 08:45, 30 January 2019

Crystal structure of HMCES SRAP domain in complex with 6-nucleotide 3' overhang DNA

6nlc, resolution 2.00Å

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